TLR4 in skin cancer: From molecular mechanisms to clinical interventions.
TLR4 in skin cancer: From molecular mechanisms to clinical interventions.
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DOI：
10.1002/mc.23016
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发表时间：
2019-07
影响因子：
4.6
通讯作者：
Wondrak GT
中科院分区：
文献类型：
--
作者：
Dickinson SE;Wondrak GT
皮肤癌造成的健康和经济负担巨大，迫切需要开发改进的分子策略来预防和治疗皮肤癌。皮肤暴露于太阳紫外线 (UV) 辐射是皮肤癌变的一个致病因素，而 TLR4 依赖性炎症失调是急性和慢性紫外线暴露有害影响的新兴关键机制。炎症信号上游的直接和间接 TLR4 激活是由多种刺激引起的，包括暴露于环境应激源（如太阳紫外线）时形成的病原体相关分子模式（如脂多糖）和损伤相关分子模式（如 HMGB1）。目前，TLR4 的参与与主要类型的皮肤恶性肿瘤有关，包括非黑色素瘤皮肤癌、黑色素瘤和默克尔细胞癌。正向或负向调节 TLR4 信号传导的靶向分子干预措施已在转化、临床前和临床研究中显示出前景，可能在不久的将来使皮肤癌患者受益。
The health and economic burden imposed by skin cancer is substantial, creating an urgent need for the development of improved molecular strategies for its prevention and treatment. Cutaneous exposure to solar ultraviolet (UV) radiation is a causative factor in skin carcinogenesis, and TLR4-dependent inflammatory dysregulation is an emerging key mechanism underlying detrimental effects of acute and chronic UV exposure. Direct and indirect TLR4 activation, upstream of inflammatory signaling, is elicited by a variety of stimuli, including pathogen-associated molecular patterns (such as lipopolysaccharide) and damage-associated molecular patterns (such as HMGB1) that are formed upon exposure to environmental stressors, such as solar UV. TLR4 involvement has now been implicated in major types of skin malignancies, including nonmelanoma skin cancer, melanoma and Merkel cell carcinoma. Targeted molecular interventions that positively or negatively modulate TLR4 signaling have shown promise in translational, preclinical, and clinical investigations that may benefit skin cancer patients in the near future.
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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3.9
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通讯作者：
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影响因子：
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通讯作者：
Hoon DS
影响因子：
--
作者：
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通讯作者：
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