Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and Fertility.
Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and Fertility.
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DOI：
10.3389/fendo.2022.818272
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发表时间：
2022
影响因子：
5.2
通讯作者：
Mu D
中科院分区：
文献类型：
--
作者：
Jiang Y;Li S;Xu W;Ying J;Qu Y;Jiang X;Zhang A;Yue Y;Zhou R;Ruan T;Li J;Mu D
脑和肌肉芳香烃受体核转运子样蛋白1（BMAL 1）是昼夜节律振荡的核心成分，参与多种生理活动。越来越多的证据表明BMAL 1在生殖生理中的重要作用。例如，BMAL 1基因敲除（KO）小鼠是不育的，生殖器官和配子受损。此外，在BMAL 1-KO小鼠中，下丘脑-垂体-性腺（H-P-G）激素的激素分泌和信号传导也被破坏，表明BMAL 1-KO小鼠中的H-P-G轴受损。此外，BMAL 1-KO小鼠和体外培养的类固醇生成细胞中通过小干扰RNA（siRNA）敲低BMAL 1均显示BMAL 1与性腺类固醇生成和相关基因的表达相关。重要的是，BMAL 1还参与人类生殖疾病的发病机制。在这篇综述中，我们详细阐述了BMAL 1-KO小鼠的生殖功能受损，包括生殖器官，生殖内分泌激素和生殖过程，突出了BMAL 1在生育和生殖内分泌学中的重要作用。
Brain and muscle aryl-hydrocarbon receptor nuclear translocator like protein1 (BMAL1), a core component of circadian oscillation, is involved in many physiological activities. Increasing evidence has demonstrated the essential role of BMAL1 in reproductive physiology. For instance, BMAL1-knockout (KO) mice were infertile, with impaired reproductive organs and gametes. Additionally, in BMAL1-KO mice, hormone secretion and signaling of hypothalamus-pituitary-gonadal (H-P-G) hormones were also disrupted, indicating that H-P-G axis was impaired in BMAL1-KO mice. Moreover, both BMAL1-KO mice and BMAL1-knockdown by small interfering RNA (siRNA) in vitro cultured steroidogenic cells showed that BMAL1 was associated with gonadal steroidogenesis and expression of related genes. Importantly, BMAL1 also participates in pathogenesis of human reproductive diseases. In this review, we elaborate on the impaired reproduction of BMAL1-KO mice including the reproductive organs, reproductive endocrine hormones, and reproductive processes, highlighting the vital role of BMAL1 in fertility and reproductive endocrinology.
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发表时间：
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期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
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通讯作者：
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