The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond.
The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond.
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DOI：
10.3389/fimmu.2018.01682
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发表时间：
2018
影响因子：
7.3
通讯作者：
Boehncke WH
中科院分区：
文献类型：
--
作者：
Brembilla NC;Senra L;Boehncke WH
银屑病是一种常见的慢性炎症性皮肤病，如今被认为是全球主要的健康问题。几种靶向IL-23/IL-17 A通路的新药最近已获得许可或正在临床开发中。这些疗法代表了银屑病治疗方式的重大改进，因为它们对银屑病的皮肤症状表现出前所未有的疗效。这已经成为可能，这要归功于越来越准确的银屑病致病观点。今天，Th 17细胞介导银屑病的信念正在转向银屑病作为IL-17 A驱动的疾病的概念。新的问题出现在地平线上，因为IL-17 A是新描述的细胞因子家族的一部分，该家族具有五种不同的同源物：IL-17 B，IL-17 C，IL-17 D，IL-17 E，也称为IL-25和IL-17 F。IL-17家族细胞因子在靶细胞中引起类似的作用，但同时以组织特异性方式触发不同的且有时相反的功能。这是复杂的事实，IL-17细胞因子显示出与其他炎症刺激的协同作用的高能力。在这篇综述中，我们将总结目前的知识，属于IL-17家族的细胞因子与皮肤炎症，特别是银屑病，并讨论可能的临床意义。全面了解IL-17细胞因子所起的不同作用对于理解当前和正在开发的疗法以及允许有效的发病机制和机制驱动的药物设计至关重要。
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been recently licensed or are in clinical development. These therapies represent a major improvement of the way in which psoriasis is managed, since they show an unprecedented efficacy on skin symptoms of psoriasis. This has been made possible, thanks to an increasingly more accurate pathogenic view of psoriasis. Today, the belief that Th17 cells mediate psoriasis is moving to the concept of psoriasis as an IL-17A-driven disease. New questions arise at the horizon, given that IL-17A is part of a newly described family of cytokines, which has five distinct homologous: IL-17B, IL-17C, IL-17D, IL-17E, also known as IL-25 and IL-17F. IL-17 family cytokines elicit similar effects in target cells, but simultaneously trigger different and sometimes opposite functions in a tissue-specific manner. This is complicated by the fact that IL-17 cytokines show a high capacity of synergisms with other inflammatory stimuli. In this review, we will summarize the current knowledge around the cytokines belonging to the IL-17 family in relation to skin inflammation in general and psoriasis in particular, and discuss possible clinical implications. A comprehensive understanding of the different roles played by the IL-17 cytokines is crucial to appreciate current and developing therapies and to allow an effective pathogenesis- and mechanisms-driven drug design.
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1161/atvbaha.116.307892
发表时间：
2016-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
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作者：
Butcher MJ;Waseem TC;Galkina EV
通讯作者：
Galkina EV
DOI：
10.1084/jem.20060244
发表时间：
2006-11-27
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Chan JR;Blumenschein W;Murphy E;Diveu C;Wiekowski M;Abbondanzo S;Lucian L;Geissler R;Brodie S;Kimball AB;Gorman DM;Smith K;de Waal Malefyt R;Kastelein RA;McClanahan TK;Bowman EP
通讯作者：
Bowman EP