Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age.
Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age.
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DOI：
10.1186/s13048-020-00734-4
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发表时间：
2020-11-24
影响因子：
4
通讯作者：
Peng C
中科院分区：
文献类型：
--
作者：
O'Brien J;Du KY;Peng C
据报道，男性和年龄较大与 COVID-19 的较差结果有关。据推测，雌激素可能在减轻疾病严重程度方面发挥作用，因此可能为 COVID-19 患者提供一种治疗选择。然而，加拿大记录了更多女性因 COVID-19 感染病例和死亡的情况。为了确定雌激素的潜在作用，我们分析了来自加拿大的 COVID-19 数据，重点关注性别和年龄的影响。虽然女性总体发病率高于男性，但排除包括医护人员和长期护理院等以女性为主的几个高危人群后，我们发现20岁至70岁之间女性的发病率低于男性。有趣的是，这种基于性别的差异在育龄女性（20-49 岁）中比绝经后患者（60 多岁或以上）更为明显。男性的住院率、ICU 入住率和病死率明显更高；然而，在年龄较大的群体中观察到更大的差异。最后，不同性别的症状表现也不同。一些症状在康复患者中比在死亡患者中更常见，与男性相比，在育龄女性中更常见。由于只有育龄女性的循环雌激素比男性高得多，因此这些研究结果表明雌激素可能在减少 COVID-19 发病率和症状的发展中发挥作用，尤其是与更好的生存相关的症状。
Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a treatment option for COVID-19 patients. However, more female cases and deaths from COVID-19 have been recorded in Canada. To determine the potential role of estrogens, we analyzed COVID-19 data from Canada, focusing on the impact of sex and age. Although the overall incidence rate is higher in females than in males, when several high risk groups, including health care workers and long-term care residences, which are predominantly females, were excluded, we found that females had a lower incidence rate than males between the ages of 20s to 70s. Interestingly, this sex-based difference is more evident in females of the reproductive ages (20–49) than in postmenopausal patients (60s or older). Males have significantly higher hospitalization, ICU admission, and case fatality rates; however, a greater difference was observed in the older age groups. Finally, symptom manifestation varied between sexes. Some of the symptoms, which were more frequently observed in patients who recovered than patients who died, were more commonly observed in females of the reproductive age compared to their male counterparts. Since only females of the reproductive age have much higher circulating estrogens than males, these findings suggest that estrogens may play a role in reducing COVID-19 incidence and in the development of symptoms, especially those related to better survival.
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影响因子：
3.7
作者：
Kalyanaraman Marcello R;Dolle J;Grami S;Adule R;Li Z;Tatem K;Anyaogu C;Apfelroth S;Ayinla R;Boma N;Brady T;Cosme-Thormann BF;Costarella R;Ford K;Gaither K;Jacobson J;Kanter M;Kessler S;Kristal RB;Lieber JJ;Mukherjee V;Rizzo V Jr;Rowell M;Stevens D;Sydney E;Wallach A;Chokshi DA;Davis N;New York City Health + Hospitals COVID-19 Population Health Data Team
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影响因子：
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通讯作者：
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影响因子：
7.3
作者：
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通讯作者：
Guéry JC