Breast cancer risk in Ukrainian women exposed to Chornobyl fallout while pregnant or lactating: standardized incidence ratio analysis, 1998 to 2016.
Breast cancer risk in Ukrainian women exposed to Chornobyl fallout while pregnant or lactating: standardized incidence ratio analysis, 1998 to 2016.
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DOI：
10.1007/s10654-022-00913-1
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发表时间：
2022-11
影响因子：
13.6
通讯作者：
Cahoon, Elizabeth K.
中科院分区：
文献类型：
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作者：
Vij, Vibha;Shpak, Victor;Zamotayeva, Galyna;Lapikura, Oles;Ryzhov, Anton;Gorokh, Evgeniy;Zhang, Rui;Mabuchi, Kiyohiko;Little, Mark P.;Drozdovitch, Vladimir;Chizhov, Konstantin;Masuik, Sergii;Preston, Dale;Tronko, Mykola;Cahoon, Elizabeth K.
Chornobyl事故后女性患乳腺癌的辐射相关风险仍不确定。在怀孕期间，乳房中的细胞迅速增殖，而接触尘埃的放射性碘可以集中在哺乳期的乳房组织中。我们对2,631名处于哺乳期和/或孕期的2,631名妇女进行了乳腺癌标准化发病率(SIR)分析，这些妇女在放射性碘的2个月期间(1986年4月26日至1986年6月30日)处于任何时刻。有37,151人年的跟踪调查，通过与乌克兰国家癌症登记中心的联系，确定了26起乳腺癌事件。将孕妇或哺乳期妇女的乳腺癌发病率与总人口发病率进行比较，并根据出生、城市/农村、年龄和日历年对SIR进行调整。SIR对于事故发生时怀孕的妇女(SIR=0.75；95%CI为0.44，1.18)和事故发生后2个月内任何时间哺乳的妇女(SIR=0.96；95%CI为0.48，1.68)均无显著意义。然而，女性在事故发生时哺乳的风险并没有显著增加(SIR=1.30，95%CI 0.40，3.01)。哺乳期妇女患乳腺癌的SIR增加与白俄罗斯的一项类似研究的结果一致，表明有必要在一项更大规模的研究中量化乳腺癌的辐射风险，这项研究涉及在接触粉尘期间哺乳的妇女。
The radiation-related risk of breast cancer among women following the Chornobyl accident remains uncertain. During pregnancy, there is rapid cell proliferation in the breast while radioactive iodine from fallout exposure can concentrate in lactating breast tissues. We conducted a standardized incidence ratio (SIR) analysis of breast cancer in a cohort of 2,631 women who were lactating and/or pregnant at any time during the 2-month period of radioiodine fallout (April 26, 1986–June 30, 1986). There were 37,151 person-years of follow-up, and 26 incident breast cancers were identified through linkage with the National Cancer Registry of Ukraine. Breast cancer rates among pregnant or lactating women were compared to the general population rates, and SIRs were adjusted for oblast, urban/rural, age, and calendar year. The SIR was not significant for women pregnant at the time of the accident (SIR = 0.75; 95% CI 0.44, 1.18) or for women lactating anytime within 2 months of the accident (SIR = 0.96; 95% CI 0.48, 1.68). However, there was a non-significantly elevated risk for women lactating at the time of accident (SIR = 1.30, 95% CI 0.40, 3.01). The increased SIR for breast cancer among lactating women is consistent with the results of a similar study in Belarus and indicates the need to quantify the radiation risk of breast cancer in a larger study of women lactating during the period of fallout exposure.
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影响因子：
5.8
作者：
Hatch, M.;Brenner, A.;Tronko, M.
通讯作者：
Tronko, M.
影响因子：
2.2
作者：
Likhtarov, Ilya;Kovgan, Lina;Bouville, Andre
通讯作者：
Bouville, Andre
影响因子：
7.7
作者：
Rivkind, Nikolai;Stepanenko, Valeriy;Davis, Scott
通讯作者：
Davis, Scott
影响因子：
7.7
作者：
Cahoon, Elizabeth K.;Preston, Dale;Velalkin, Ilya V.
通讯作者：
Velalkin, Ilya V.
影响因子：
6.4
作者：
通讯作者：
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