In vivo confocal microscopy qualitative investigation of the relationships between lattice corneal dystrophy deposition and corneal nerves.
In vivo confocal microscopy qualitative investigation of the relationships between lattice corneal dystrophy deposition and corneal nerves.
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活体共焦显微镜定性研究格子状角膜营养不良沉积与角膜神经的关系。
DOI：
10.1186/s12886-021-02149-1
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发表时间：
2021-12-27
影响因子：
2
通讯作者：
Nie D
中科院分区：
文献类型：
--
作者：
Zhu F;Li M;Zhang C;Chen C;Ying F;Nie D
利用活体激光扫描共聚焦显微镜（IVCM）研究格子状角膜营养不良（LCD）患者的角膜神经营养现象。每年对总共 15 名患有 LCD 的患者（28 只眼睛）进行 IVCM 随访。收集数据进行分析。分析显示，LCD患者的正常角膜基质神经（0级）随着随访时间的延长而呈现下降趋势，而涉及淀粉样蛋白包裹神经纤维的I级和II级逐渐增加，这表明由于角膜神经侵袭而导致的淀粉样蛋白沉积量随着时间的推移而缓慢增加。 LCD患者角膜病变的亲神经现象随病变程度的加重而加重，在一定程度上也反映了角膜神经的分布情况。 IVCM提供了一种快速、无创的观察角膜神经的方法，这可以成为更好地了解LCD发展的有效手段。在线版本包含可在 10.1186/s12886-021-02149-1 获取的补充材料。
To investigate the corneal neurotropic phenomenon in patients with lattice corneal dystrophy (LCD) with in vivo laser scanning confocal microscopy (IVCM). IVCM was performed on a total of 15 patients (28 eyes) with LCD annually at a follow-up. A collection of the data was acquired to be analyzed. As indicated by the analysis, the LCD patients’ normal corneal stromal nerves (Grade 0) presented a decline with the prolongation of the follow-ups, corresponding to a gradual increase in grade I and II involving amyloid-wrapped nerve fibers, which demonstrated that the growing amount of amyloid deposit due to the corneal nerve invasion increased slowly over time. The neurotropic phenomenon could increase with its severity in the corneal lesion of the patients with LCD, and also reflect the distribution of the corneal nerves, to some extent. IVCM provides a rapid, noninvasive way to observe the corneal nerves, which can be an efficient means of better understanding the development of LCD. The online version contains supplementary material available at 10.1186/s12886-021-02149-1.
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DOI：
10.1016/j.jtos.2016.09.004
发表时间：
2017-01
期刊：
The ocular surface
影响因子：
--
作者：
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通讯作者：
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影响因子：
2.8
作者：
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影响因子：
81.5
作者：
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DOI：
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发表时间：
2015
期刊：
Case reports in ophthalmological medicine
影响因子：
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影响因子：
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作者：
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