An epidemic analysis of hand, foot, and mouth disease in Zunyi, China between 2012 and 2014.
An epidemic analysis of hand, foot, and mouth disease in Zunyi, China between 2012 and 2014.
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DOI：
10.15537/smj.2015.5.10859
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发表时间：
2015-05
影响因子：
1.6
通讯作者：
Wu K
中科院分区：
文献类型：
--
作者：
Zhang W;Huang B;She C;Liu Y;Tong H;Wang F;Wu K
目的重新评估遵义市手足口病（HFMD）在未接种疫苗人群中的流行病学。我们使用来自中国遵义医学院第三附属医院的实验室数据来评估2012年1月至2014年11月期间肠道病毒引起的手足口病的流行病学。实时聚合酶链反应被用来确定人类肠道病毒从共12313例可能的情况下，在这项回顾性研究。所有分析均按肠道病毒血清型、性别和年龄分层。12313例疑似手足口病病例的病毒学结果可用。共检出病毒阳性5750例，其他肠道病毒感染阳性率为46.7%，其中EV 71型阳性率为9%，CVA 16型阳性率为4.7%。在研究期间，手足口病的发病率大幅上升。大多数手足口病患者（87.4%）的年龄为0-59个月（中位数24;范围0-59）。男性手足口病患病率（62.4%）高于女性（37.6%）。肠道病毒感染仍然是一个重要的公共卫生问题，其他肠道病毒正在成为中国遵义手足口病的主要病原体。
To re-evaluate the epidemiology of hand, foot, and mouth disease (HFMD) in a non-vaccinated population in Zunyi, China. We used laboratory-based data from the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China to assess the epidemiology of the HFMD caused by enteroviruses between January 2012 and November 2014. Real-time polymerase chain reaction was used to determine human enteroviruses from a total of 12313 probable cases enrolled in this retrospective study. All analyses were stratified by enterovirus serotype, gender, and age. Virological results were available for 12313 cases of probable HFMD. A total of 5750 cases were positive for viral detection, and the positive rates of infection caused by other enteroviruses was 46.7%, EV71 9%, and CVA16 4.7%. During the study period there was a substantial increase in the occurrence of HFMD. Most of the HFMD patients (87.4%) were aged 0-59 months (median 24; range 0-59). Males showed a higher HFMD prevalence rate (62.4%) than females (37.6%). Enterovirus infection remains an important public health problem and other entroviruses are emerging as the major causative agent of the HFMD in Zunyi, China.
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影响因子：
3.7
作者：
Wang X;Fiorini Z;Smith C;Zhang Y;Li J;Watkins LR;Yin H
通讯作者：
Yin H
影响因子：
4.8
作者：
Yip CC;Lau SK;Lo JY;Chan KH;Woo PC;Yuen KY
通讯作者：
Yuen KY
基于病毒样颗粒的二价疫苗可为小鼠提供针对肠道病毒 71 和柯萨奇病毒 A16 感染的双重保护
影响因子：
5.5
作者：
Ku, Zhiqiang;Liu, Qingwei;Huang, Zhong
通讯作者：
Huang, Zhong
影响因子：
2.1
作者：
Chang, Luan-Yin
通讯作者：
Chang, Luan-Yin
影响因子：
56.3
作者：
Xing, Weijia;Liao, Qiaohong;Viboud, Cecile;Zhang, Jing;Sun, Junling;Wu, Joseph T.;Chang, Zhaorui;Liu, Fengfeng;Fang, Vicky J.;Zheng, Yingdong;Cowling, Benjamin J.;Varma, Jay K.;Farrar, Jeremy J.;Leung, Gabriel M.;Yu, Hongjie
通讯作者：
Yu, Hongjie