Relationship between neural crest cells and cranial mesoderm during head muscle development.
Relationship between neural crest cells and cranial mesoderm during head muscle development.
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DOI：
10.1371/journal.pone.0004381
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Duprez, Delphine
中科院分区：
文献类型：
--
作者：
Grenier, Julien;Teillet, Marie-Aimee;Grifone, Raphaelle;Kelly, Robert G.;Duprez, Delphine
在脊椎动物中，颌骨的骨骼成分，以及结缔组织和肌腱，起源于神经嵴细胞，而相关的肌肉主要来自颅中胚层。先前的研究表明，神经嵴细胞迁移与颅中胚层密切相关，然后在发育的早期阶段限制但不穿透鳃弓肌肉前体细胞的核心，从而在神经嵴细胞和中胚层肌肉祖细胞之间定义了一个清晰的边界。肌腱构成神经嵴衍生物之一，可能与肌肉形成相互作用。然而，头部肌腱的形成还没有被研究，也没有肌腱和肌肉在头部的相互作用。重新调查颅神经嵴细胞和肌肉前体细胞之间的关系，在发展过程中的第一鳃弓，鹌鹑/鸡嵌合体和分子标记揭示了几个新的功能，神经嵴细胞和中胚层之间的接口。我们观察到，神经嵴细胞迁移到头部中胚层含肌源性前体细胞，导致第一鳃弓的中胚层核心内的神经嵴细胞的存在。我们还建立了所有形成肌腱与鳃节和眼肌的神经嵴起源和表达Scleraxis标记在鸡和小鼠胚胎。此外，在Tbx 1 −/−突变小鼠中缺乏鳃节肌的情况下对巩膜轴表达的分析表明，肌肉对于肌腱形成的起始不是必需的，但对于进一步的肌腱发育是必需的。这一结果表明，神经嵴细胞和肌肉祖细胞更广泛地混合比以前认为在弓的发展。此外，我们的研究结果表明，在颅面发育过程中肌肉和肌腱之间的相互作用是相似的，在肢体中观察到的，尽管这些细胞类型在头部不同的胚胎学起源。
In vertebrates, the skeletal elements of the jaw, together with the connective tissues and tendons, originate from neural crest cells, while the associated muscles derive mainly from cranial mesoderm. Previous studies have shown that neural crest cells migrate in close association with cranial mesoderm and then circumscribe but do not penetrate the core of muscle precursor cells of the branchial arches at early stages of development, thus defining a sharp boundary between neural crest cells and mesodermal muscle progenitor cells. Tendons constitute one of the neural crest derivatives likely to interact with muscle formation. However, head tendon formation has not been studied, nor have tendon and muscle interactions in the head. Reinvestigation of the relationship between cranial neural crest cells and muscle precursor cells during development of the first branchial arch, using quail/chick chimeras and molecular markers revealed several novel features concerning the interface between neural crest cells and mesoderm. We observed that neural crest cells migrate into the cephalic mesoderm containing myogenic precursor cells, leading to the presence of neural crest cells inside the mesodermal core of the first branchial arch. We have also established that all the forming tendons associated with branchiomeric and eye muscles are of neural crest origin and express the Scleraxis marker in chick and mouse embryos. Moreover, analysis of Scleraxis expression in the absence of branchiomeric muscles in Tbx1−/− mutant mice, showed that muscles are not necessary for the initiation of tendon formation but are required for further tendon development. This results show that neural crest cells and muscle progenitor cells are more extensively mixed than previously believed during arch development. In addition, our results show that interactions between muscles and tendons during craniofacial development are similar to those observed in the limb, despite the distinct embryological origin of these cell types in the head.
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DOI：
10.1073/pnas.0604751103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Brito, Jose M.;Teillett, Marie-Aimee;Le Douarin, Nicole M.
通讯作者：
Le Douarin, Nicole M.
影响因子：
4.6
作者：
Dong, Feiyan;Sun, Xiaoxia;Martin, James F.
通讯作者：
Martin, James F.
影响因子：
11.4
作者：
Grifone, Raphaeelle;Kelly, Robert G.
通讯作者：
Kelly, Robert G.
影响因子：
2.7
作者：
Edom-Vovard, F;Schuler, B;Duprez, D
通讯作者：
Duprez, D
影响因子：
9.2
作者：
Ahlgren, SC;Bronner-Fraser, M
通讯作者：
Bronner-Fraser, M