Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors.
Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors.
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DOI：
10.3389/fnbeh.2014.00269
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发表时间：
2014
影响因子：
3
通讯作者：
Lee S
中科院分区：
文献类型：
--
作者：
Park K;Song S;Hong I;Song B;Kim J;Park S;Lee J;Song S;An B;Kim J;Lee CJ;Shin KS;Choi S;Lee S
关于钙渗透性受体是否在 I 组 mGluR 介导的突触抑制期间被去除，存在相互矛盾的证据。为了支持这一假设，AMPAR 整流是缺乏 GluA2 的钙渗透性 AMPAR (CP-AMPAR) 突触表达的相关指数，已知在诱导几种类型的 I 组 mGluR 介导的长期抑制 (LTD) 后会降低，这表明在突触抑制期间很大一部分突触 CP-AMPAR 被去除。我们之前已经证明，恐惧条件诱导的外侧杏仁核突触增强可被 1 组 mGluR 介导的去增强作用逆转。在这里，我们检查了 CP-AMPAR 是否通过 mGluR1 介导的恐惧条件诱导的突触增强的去增强作用而被去除。 CP-AMPAR 的突触表达在之前可以忽略不计，在恐惧调节后 12 小时显着增加，并在恐惧调节后 48 小时恢复到基线，外侧杏仁核突触对 NASPM 反应敏感性的变化证明了这一点。重要的是，诱导去潜能后，对 NASPM 的敏感性没有改变。我们的研究结果与之前的结果一起表明，去除 CP-AMPAR 并不是恐惧条件诱导的外侧杏仁核突触增强作用减弱所必需的。
There is conflicting evidence regarding whether calcium-permeable receptors are removed during group I mGluR-mediated synaptic depression. In support of this hypothesis, AMPAR rectification, a correlative index of the synaptic expression of GluA2-lacking calcium–permeable AMPARs (CP-AMPARs), is known to decrease after the induction of several types of group I mGluR-mediated long-term depression (LTD), suggesting that a significant proportion of synaptic CP-AMPARs is removed during synaptic depression. We have previously demonstrated that fear conditioning-induced synaptic potentiation in the lateral amygdala is reversed by group 1 mGluR-mediated depotentiation. Here, we examined whether CP-AMPARs are removed by mGluR1-mediated depotentiation of fear conditioning-induced synaptic potentiation. The synaptic expression of CP-AMPARs was negligible before, increased significantly 12 h after, and returned to baseline 48 h after fear conditioning, as evidenced by the changes in the sensitivity of lateral amygdala synaptic responses to NASPM. Importantly, the sensitivity to NASPM was not altered after induction of depotentiation. Our findings, together with previous results, suggest that the removal of CP-AMPARs is not required for the depotentiation of fear conditioning-induced synaptic potentiation at lateral amygdala synapses.
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影响因子：
5.3
作者：
Clem, Roger L.;Huganir, Richard L.
通讯作者：
Huganir, Richard L.
DOI：
10.1073/pnas.0710548105
发表时间：
2007-12-26
影响因子：
11.1
作者：
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通讯作者：
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作者：
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通讯作者：
Wolf ME
影响因子：
2
作者：
Knapska, Ewelina;Maren, Stephen
通讯作者：
Maren, Stephen