Androgenicity in Young Women and Development of Metabolic Syndrome Before Menopause: The CARDIA and CARDIA Women's Studies.
Androgenicity in Young Women and Development of Metabolic Syndrome Before Menopause: The CARDIA and CARDIA Women's Studies.
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年轻女性的雄激素性和绝经前代谢综合征的发展：CARDIA 和 CARDIA 女性研究。
DOI：
10.1210/jendso/bvad174
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发表时间：
2024-01-05
影响因子：
4.1
通讯作者：
Daviglus, Martha L.
中科院分区：
文献类型：
--
作者：
Vu, Thanh-Huyen T.;Pirzada, Amber;Lewis, Cora E.;Schreiner, Pamela J.;Liu, Kiang;Sternfeld, Barbara;Calderon-Margalit, Ronit;Merkin, Sharon S.;Wellons, Melissa;Williams, O. Dale;Kim, Catherine;Siscovick, David S.;Daviglus, Martha L.
关键词：
There are no reported data from prospective long-term studies on the relation of androgen levels in young women with development of metabolic syndrome (MetS) before menopause. We investigated associations of androgens and SHBG with incident MetS during 23 years of follow-up. We included 366 White and 375 Black women ages 20 to 32 years participating in the CARDIA study and CARDIA Women’s study, free of MetS at baseline examination (1987-1988), and premenopausal 23 years later. Androgens and SHBG were categorized into quartiles. MetS was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Cox proportional hazards models were used. By year 23, 30% of women developed MetS. Adjusting for baseline age, race, and education, hazard ratios (95% CI) of developing MetS were 1.46 (1.02-2.10) and 2.22 (1.53-3.21) for women in the highest vs lowest total testosterone (T) and free T quartile, respectively. The hazards of developing MetS were 47%, 59%, and 53% lower for women with SHBG in the second, third, and fourth quartiles (vs lowest quartile), respectively. Associations were attenuated for total T with further adjustments for smoking, physical activity, menstrual status, oral contraceptive/hormone (OCHM) use, insulin level, oligomenorrhea, and age at menarche, but remained statistically significant for free T and SHBG. Associations were similar for both Blacks and Whites, and OCHM nonusers, but not for OCHM users. High androgenicity in young premenopausal women is associated with higher risk of future MetS, suggesting that early assessment of androgens may contribute to prevention.
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影响因子：
16.2
作者：
Isomaa, B;Almgren, P;Groop, L
通讯作者：
Groop, L
影响因子：
1.8
作者：
Andreadis, E. A.;Katsanou, P. M.;Diamantopoulos, E. J.
通讯作者：
Diamantopoulos, E. J.
DOI：
10.1152/ajpcell.1998.274.6.c1645
发表时间：
1998-06-01
影响因子：
5.5
作者：
Dieudonné, MN;Pecquery, R;Giudicelli, Y
通讯作者：
Giudicelli, Y
影响因子：
5
作者：
Golden, SH;Ding, J;Dobs, A
通讯作者：
Dobs, A
DOI：
10.1097/00008483-198911000-00003
发表时间：
1989-11-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Jacobs, David R Jr;Hahn, Lorraine P;Sidney, Stephen
通讯作者：
Sidney, Stephen