Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise.

Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise.
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DOI:
10.1016/j.jmig.2015.02.021
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发表时间:
2015-07
影响因子:
4.1
通讯作者:
Lue, John R.
Lue, John R.
中科院分区:
医学2区
文献类型:
--
作者:
Nothnick, Warren B.;Al-Hendy, Ayman;Lue, John R.

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Endometriosis represents a major medical concern in women of reproductive age. One of the major hurdles in successful treatment of endometriosis that remains is the limitation in the process of timely disease diagnosis. A simple blood test for endometriosis-specific biomarkers would offer a timelier, accurate diagnosis for the disease allowing earlier treatment intervention. While there have been considerable efforts to identify such biomarkers, no clear choice for such non-invasive diagnostic tools have been identified. MicroRNAs are small non-coding RNAs which have been intensively evaluated as biomarkers for several diseases and may hold promise for endometriosis diagnosis. In this review, we highlight the need for non-invasive testing for endometriosis, discuss the potential use of miRNAs as diagnostic tools for this disease, and consider potential limitations in the use of these small RNA molecules as diagnostic markers for endometriosis.
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