Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1.
Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1.
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DOI：
10.3390/v13020344
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发表时间：
2021-02-22
期刊：
影响因子：
--
通讯作者：
Falfán-Valencia R
中科院分区：
文献类型：
--
作者：
Pérez-Rubio G;Ponce-Gallegos MA;Domínguez-Mazzocco BA;Ponce-Gallegos J;García-Ramírez RA;Falfán-Valencia R
甲型流感病毒 (IAV) 是人类最常见的传染源，感染世界上大约 10-20% 的人口，每年导致 3-500 万人住院。使用 PubMed 数据库和医学主题词 (MeSH)“甲型 H1N1 流感”和“遗传易感性”进行科学文献检索。由于上次甲型 H1N1 流感大流行中进行的研究产生了大量有关遗传易感性的信息和证据，因此考虑了 2009 年 1 月至 2020 年 5 月期间发表的研究；共找到 119 篇论文。宿主防御 IAV 感染涉及多种途径（先天免疫反应、促炎细胞因子、趋化因子、补体激活和参与病毒抗原呈递的 HLA 分子）。另一方面，单核苷酸多态性（SNP）是一种涉及单个碱基对变化的变异，这可能意味着编码的蛋白质无法正常发挥其功能，从而导致病毒复制速度加快和宿主对感染的异常反应，例如细胞因子风暴。一些研究最多的与 IAV 感染遗传易感性相关的 SNP 位于 FCGR2A、C1QBP、CD55 和 RPAIN 基因中，通过异常补体激活影响宿主免疫反应。此外，IFITM3（参与内体和溶酶体融合）中的 SNP 代表了与 IAV 感染相关的一些最关键的多态性，表明病毒清除无效。关于炎症反应基因，IL1B、TNF、LTA、IL17A、IL8、IL6、IRAK2、PIK3CG 和 HLA 复合体中的单核苷酸变异与促炎症分子的表型改变相关，参与 IAV 感染和最严重的疾病形式。
Influenza A virus (IAV) is the most common infectious agent in humans, and infects approximately 10–20% of the world’s population, resulting in 3–5 million hospitalizations per year. A scientific literature search was performed using the PubMed database and the Medical Subject Headings (MeSH) “Influenza A H1N1” and “Genetic susceptibility”. Due to the amount of information and evidence about genetic susceptibility generated from the studies carried out in the last influenza A H1N1 pandemic, studies published between January 2009 to May 2020 were considered; 119 papers were found. Several pathways are involved in the host defense against IAV infection (innate immune response, pro-inflammatory cytokines, chemokines, complement activation, and HLA molecules participating in viral antigen presentation). On the other hand, single nucleotide polymorphisms (SNPs) are a type of variation involving the change of a single base pair that can mean that encoded proteins do not carry out their functions properly, allowing higher viral replication and abnormal host response to infection, such as a cytokine storm. Some of the most studied SNPs associated with IAV infection genetic susceptibility are located in the FCGR2A, C1QBP, CD55, and RPAIN genes, affecting host immune responses through abnormal complement activation. Also, SNPs in IFITM3 (which participates in endosomes and lysosomes fusion) represent some of the most critical polymorphisms associated with IAV infection, suggesting an ineffective virus clearance. Regarding inflammatory response genes, single nucleotide variants in IL1B, TNF, LTA IL17A, IL8, IL6, IRAK2, PIK3CG, and HLA complex are associated with altered phenotype in pro-inflammatory molecules, participating in IAV infection and the severest form of the disease.
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DOI：
10.3390/v12111224
发表时间：
2020-10-29
期刊：
Viruses
影响因子：
--
作者：
Ponce-Gallegos MA;Ruiz-Celis A;Ambrocio-Ortiz E;Pérez-Rubio G;Ramírez-Venegas A;Bautista-Félix NE;Falfán-Valencia R
通讯作者：
Falfán-Valencia R
影响因子：
2.7
作者：
Alagarasu, K.;Mulay, A. P.;Cecilia, D.
通讯作者：
Cecilia, D.
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
3.7
作者：
García-Ramírez RA;Ramírez-Venegas A;Quintana-Carrillo R;Camarena ÁE;Falfán-Valencia R;Mejía-Aranguré JM
通讯作者：
Mejía-Aranguré JM
影响因子：
3.6
作者：
Ambrocio-Ortiz, Enrique;Galicia-Negrete, Gustavo;Falfan-Valencia, Ramces
通讯作者：
Falfan-Valencia, Ramces