Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population.
Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population.
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DOI：
10.3390/v12111224
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发表时间：
2020-10-29
期刊：
影响因子：
--
通讯作者：
Falfán-Valencia R
中科院分区：
文献类型：
--
作者：
Ponce-Gallegos MA;Ruiz-Celis A;Ambrocio-Ortiz E;Pérez-Rubio G;Ramírez-Venegas A;Bautista-Félix NE;Falfán-Valencia R
(1)背景：甲型H1N1流感病毒pdm 09在全世界迅速传播。尽管在甲型流感病毒（IAV）感染的发病机制中描述了炎症和病毒降解途径，但对参与加工和抗原呈递相关机制的基因中的单核苷酸多态性（SNP）的作用知之甚少。(2)方法：在这项病例对照研究中，我们评估了5个基因（TAP 1，TAP 2，TAPBP，PSMB 8和PSMB 9）的17个SNP。纳入了128例甲型H1N1流感感染（INF-P）患者和111例健康接触者（HC）;他们都是墨西哥混血儿。(3)结果如下：在等位基因和基因型比较中，rs 241433/C等位基因（TAP 2）以及AG单倍型（rs3763365和rs 4148882）与甲型H1N1流感感染风险降低相关（p < 0.05）。另一方面，rs 2071888 G等位基因（TAPBP）和GG单倍型（rs3763365和rs 9276810）与甲型H1N1流感感染的高风险相关。此外，在调整协变量后，rs 241433/C等位基因与甲型H1N1流感感染风险降低的相关性仍然存在。（p < 0.0001，OR = 0.24，95%CI = 0.13-0.43），G等位基因与TAPBP的相关性也保持不变GG基因型模型（p <0.05，OR = 2.18，95% CI = 1.27-3.74）。(4)结论：rs 241433/C等位基因、AC基因型（TAP 2）和AG单倍型与甲型H1N1流感感染风险降低相关。此外，rs 2071888/G等位基因和GG基因型（TAPBP）和GG单倍型与墨西哥混血人群中发生甲型流感/H1N1感染的风险较高相关。
(1) Background: The influenza A/H1N1 pdm09 virus rapidly spread throughout the world. Despite the inflammatory and virus-degradation pathways described in the pathogenesis of influenza A virus (IAV) infection, little is known about the role of the single nucleotide polymorphisms (SNPs) in the genes involved in the processing and antigenic presentation-related mechanisms. (2) Methods: In this case-control study, we evaluated 17 SNPs in five genes (TAP1, TAP2, TAPBP, PSMB8, and PSMB9). One hundred and twenty-eight patients with influenza A/H1N1 infection (INF-P) and 111 healthy contacts (HC) were included; all of them are Mexican mestizo. (3) Results: In allele and genotype comparison, the rs241433/C allele (TAP2), as well as AG haplotype (rs3763365 and rs4148882), are associated with reduced risk for influenza A/H1N1 infection (p < 0.05). On the other hand, the rs2071888G allele (TAPBP) and GG haplotype (rs3763365 and rs9276810) are associated with a higher risk for influenza A/H1N1 infection. In addition, after adjustment for covariates, the association to a reduced risk for influenza A/H1N1 infection remains with rs241433/C allele (p < 0.0001, OR = 0.24, 95% CI = 0.13–0.43), and the association with TAPBP is also maintained with the G allele (p = 0.0095, OR = 1.89, 95% CI = 1.17–3.06) and GG genotype models (p < 0.05, OR = 2.18, 95% CI = 1.27–3.74). (4) Conclusion: The rs241433/C allele and AC genotype (TAP2) and the AG haplotype are associated with a reduced risk for influenza A/H1N1 infection. In addition, the rs2071888/G allele and GG genotype (TAPBP) and the GG haplotype are associated with a higher risk for developing influenza A/H1N1 infection in a Mexican mestizo population.
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影响因子：
4.1
作者：
Falfán-Valencia R;Narayanankutty A;Reséndiz-Hernández JM;Pérez-Rubio G;Ramírez-Venegas A;Nava-Quiroz KJ;Bautista-Félix NE;Vargas-Alarcón G;Castillejos-López MDJ;Hernández A
通讯作者：
Hernández A
影响因子：
3.7
作者：
García-Ramírez RA;Ramírez-Venegas A;Quintana-Carrillo R;Camarena ÁE;Falfán-Valencia R;Mejía-Aranguré JM
通讯作者：
Mejía-Aranguré JM
影响因子：
168.9
作者：
Echevarria-Zuno, Santiago;Manuel Mejia-Arangure, Juan;Hugo Borja-Aburto, Victor
通讯作者：
Hugo Borja-Aburto, Victor
DOI：
10.1186/cc8208
发表时间：
2009
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bermejo-Martin JF;Ortiz de Lejarazu R;Pumarola T;Rello J;Almansa R;Ramírez P;Martin-Loeches I;Varillas D;Gallegos MC;Serón C;Micheloud D;Gomez JM;Tenorio-Abreu A;Ramos MJ;Molina ML;Huidobro S;Sanchez E;Gordón M;Fernández V;Del Castillo A;Marcos MA;Villanueva B;López CJ;Rodríguez-Domínguez M;Galan JC;Cantón R;Lietor A;Rojo S;Eiros JM;Hinojosa C;Gonzalez I;Torner N;Banner D;Leon A;Cuesta P;Rowe T;Kelvin DJ
通讯作者：
Kelvin DJ
影响因子：
2.6
作者：
Cho, Sung-hwan;Park, Jong-Sook;Park, Choon-Sik
通讯作者：
Park, Choon-Sik