The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis.
The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis.
复制标题
CTLA-4、CD80/86 和 CD28 基因多态性与类风湿关节炎之间的关联：一项原始研究和荟萃分析。
DOI：
10.3389/fmed.2021.598076
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发表时间：
2021
影响因子：
3.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Liu W;Yang Z;Chen Y;Yang H;Wan X;Zhou X;Liu R;Zhang Y
Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4 and CD86 genes in different populations of RA have been studied extensively, the results are controversial. Objective: To clarify the correlation in the Chinese Han population between CTLA-4, CD80/86, and CD28 gene polymorphisms, and RA susceptibility. Methods: A case-control study (574 RA patients and 804 controls) was conducted to determine the correlation between CTLA-4 rs231775 and rs16840252 gene polymorphisms, CD86 rs17281995 gene polymorphisms, and the risk of RA for the Chinese Han population. Furthermore, an additional meta-analysis, including three single nucleotide polymorphisms (SNPs) (CTLA-4 rs231775, CTLA-4 rs3087243, and CTLA-4 rs5742909) from 32 citations, including 43 studies, 24,703 cases and 23,825 controls was performed to elucidate the relationship between known SNPs in the CTLA-4 genes and RA for more robust conclusions. Results: The results showed that CTLA-4 rs231775 gene polymorphism decreased the RA risk (GA vs. AA, OR = 0.77, P = 0.025), whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA susceptibility. Stratification analyses by RF, ACPA, CRP, ESR, DAS28, and functional class identified significant associations for CTLA-4 rs231775 and rs16840252 gene polymorphisms in the RF-positive and RF-negative groups. A meta-analysis of the literature on CTLA-4 gene polymorphisms and RA risk revealed that the risk of RA was decreased by CTLA-4 rs231775 gene polymorphisms. Conclusions: The CTLA-4 rs231775 gene polymorphism decreased the risk of RA, whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA risk. A meta-analysis indicated that CTLA-4 rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. To support these analytical results, additional clinical cases should be investigated in further studies.
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影响因子：
3.5
作者：
Ewing, M. M.;Karper, J. C.;Quax, P. H. A.
通讯作者：
Quax, P. H. A.
影响因子：
3.5
作者：
Elshazli, Rami;Settin, Ahmad;Salama, Afrah
通讯作者：
Salama, Afrah
影响因子：
3.5
作者：
Barton A;Eyre S;Ke X;Hinks A;Bowes J;Flynn E;Martin P;YEAR Consortium;BIRAC Consortium;Wilson AG;Morgan AW;Emery P;Steer S;Hocking LJ;Reid DM;Harrison P;Wordsworth P;Thomson W;Worthington J
通讯作者：
Worthington J
影响因子：
4.9
作者：
Costenbader KH;Chang SC;De Vivo I;Plenge R;Karlson EW
通讯作者：
Karlson EW
影响因子：
5.5
作者：
Kacem, HH;Kaddour, N;Ayadi, H
通讯作者：
Ayadi, H