Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication.
Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication.
复制标题
DOI：
10.1038/s41467-020-18550-1
复制
发表时间：
2020-09-21
影响因子：
16.6
通讯作者：
Prendergast JGD
中科院分区：
文献类型：
--
作者：
Dutta P;Talenti A;Young R;Jayaraman S;Callaby R;Jadhav SK;Dhanikachalam V;Manikandan M;Biswa BB;Low WY;Williams JL;Cook E;Toye P;Wall E;Djikeng A;Marshall K;Archibald AL;Gokhale S;Kumar S;Hume DA;Prendergast JGD
在全球范围内，依赖布法罗的人比任何其他驯养物种都多，作为与牛关系最密切的驯养物种，它们可以为驯养的共同进化基础提供重要的见解。在这里，我们对7个品种的79头布法罗的基因组进行了测序，并将品种选择性扫描与代表13个全球品种的294头牛的基因组进行了比较。在人类遗传学研究中，牛品种间选择的基因组区域与与身高相关区域显著重叠，这些基因座的不成比例数量也显示出在水布法罗品种间选择。对布法罗基因组中潜在功能变异的调查确定了一个罕见的趋同驯化的例子，即同一突变独立发生并在驯化物种中被选择。因此，对最近的选择性扫描进行跨物种比较可以帮助确定和改进与驯化有关的重要位点。驯化谱系的比较基因组学可以深入了解人工选择的特征。本研究对来自7个品种的79头布法罗基因组进行了测序，揭示了布法罗和黄牛在遗传水平上趋同驯化的实例。
More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes representing 13 global breeds. The genomic regions under selection between cattle breeds significantly overlap regions linked to stature in human genetic studies, with a disproportionate number of these loci also shown to be under selection between water buffalo breeds. Investigation of potential functional variants in the water buffalo genome identifies a rare example of convergent domestication down to the same mutation having independently occurred and been selected for across domesticated species. Cross-species comparisons of recent selective sweeps can consequently help identify and refine important loci linked to domestication. The comparative genomics of domesticated lineages can yield insights into the signatures of artificial selection. This study sequences 79 water buffalo genomes from 7 breeds and reveals examples of convergent domestication at the genetic level between water buffalo and cattle.
登录
查看更多内容
影响因子：
12.3
作者：
Buels R;Yao E;Diesh CM;Hayes RD;Munoz-Torres M;Helt G;Goodstein DM;Elsik CG;Lewis SE;Stein L;Holmes IH
通讯作者：
Holmes IH
影响因子：
16.6
作者：
Alberto FJ;Boyer F;Orozco-terWengel P;Streeter I;Servin B;de Villemereuil P;Benjelloun B;Librado P;Biscarini F;Colli L;Barbato M;Zamani W;Alberti A;Engelen S;Stella A;Joost S;Ajmone-Marsan P;Negrini R;Orlando L;Rezaei HR;Naderi S;Clarke L;Flicek P;Wincker P;Coissac E;Kijas J;Tosser-Klopp G;Chikhi A;Bruford MW;Taberlet P;Pompanon F
通讯作者：
Pompanon F
影响因子：
5.8
作者：
Barnett, Derek W.;Garrison, Erik K.;Marth, Gabor T.
通讯作者：
Marth, Gabor T.
影响因子：
14.9
作者：
Buniello, Annalisa;MacArthur, Jacqueline A. L.;Parkinson, Helen
通讯作者：
Parkinson, Helen
影响因子：
7
作者：
Chen, Hua;Patterson, Nick;Reich, David
通讯作者：
Reich, David