Performance on the Wechsler Adult Intelligence Scale (WAIS) in Japanese patients with bipolar and major depressive disorders in euthymic and depressed states.
Performance on the Wechsler Adult Intelligence Scale (WAIS) in Japanese patients with bipolar and major depressive disorders in euthymic and depressed states.
复制标题
DOI：
10.1111/pcn.13191
复制
发表时间：
2021-04
影响因子：
11.9
通讯作者：
Kunugi H
中科院分区：
文献类型：
--
作者：
Matsuo J;Hori H;Ishida I;Hiraishi M;Ota M;Hidese S;Yomogida Y;Kunugi H
本研究的目的是检查双相情感障碍（BD）患者的认知表现分层的疾病阶段相比，患者与重性抑郁症（MDD）和健康对照。参与者包括139例BD患者（55例正常胸腺和84例抑郁），311例MDD患者（88例正常胸腺和223例抑郁）和386例健康对照，他们接受了韦氏成人智力量表修订版或第三版。他们是非老年日本人，具有正常的估计发病前智商（IQ; >90），年龄，性别和发病前IQ组匹配。抑郁障碍组的言语智商、操作智商、全量表智商以及知觉组织、工作记忆和处理速度三项组间指标的得分均显著低于健康对照组（均P < 0.001）。工作记忆指数和智商均显著低于抑郁症组。抑郁症组在操作智商（P < 0.001）、全量表智商（P < 0.001）和处理速度指数（P < 0.001）上的得分显著低于对照组。正常胸腺BD组得分显着低于对照组的操作智商（P = 0.004），而正常胸腺MDD组得分显着低于对照组的处理速度（P = 0.030）。与抑郁症患者相比，BD患者在抑郁状态下似乎具有全球性和更强烈的认知障碍，而抑郁症患者的障碍似乎仅在韦氏成人智力量表的处理速度方面明显。减弱的损害似乎存在于这两个病人的正常状态。
This study aimed to examine the cognitive performance of patients with bipolar disorder (BD) stratified by illness phase compared to that of patients with major depressive disorder (MDD) and healthy controls. Participants were 139 patients with BD (55 euthymic and 84 depressed), 311 patients with MDD (88 euthymic and 223 depressed), and 386 healthy controls who underwent the Wechsler Adult Intelligence Scale‐Revised or the Third Edition. They were non‐elderly Japanese individuals with normal estimated premorbid intelligence quotient (IQ; >90), group‐matched for age, sex, and premorbid IQ. The depressed BD group showed significantly lower scores on verbal IQ, performance IQ, full‐scale IQ, and three group indexes of perceptual organization, working memory, and processing speed when compared with healthy controls (all P < 0.001). All IQs and working memory index were also significantly lower than those of the depressed MDD group. The depressed MDD group scored significantly lower than controls in performance IQ (P < 0.001), full‐scale IQ, and only in the index of processing speed (P < 0.001). The euthymic BD group scored significantly lower than controls in performance IQ (P = 0.004), whereas the euthymic MDD group scored significantly lower than controls only in processing speed (P = 0.030). Patients with BD appear to have global and more intense cognitive impairments in depressed states compared with those with MDD whose impairments seem to be apparent only in processing speed in the Wechsler Adult Intelligence Scale. Attenuated impairments appear to exist in euthymic states of both patients.
登录
查看更多内容
影响因子：
6.9
作者：
Burdick KE;Russo M;Frangou S;Mahon K;Braga RJ;Shanahan M;Malhotra AK
通讯作者：
Malhotra AK
影响因子：
5.3
作者：
Green, Michael F.
通讯作者：
Green, Michael F.
影响因子：
5.4
作者：
Dittmann, Sandra;Hennig-Fast, Kristina;Grunze, Heinz C.
通讯作者：
Grunze, Heinz C.
影响因子：
2.6
作者：
Crowe, Simon F.;Stranks, Elizabeth K.
通讯作者：
Stranks, Elizabeth K.
DOI：
10.1080/13803390500246944
发表时间：
2006-10-01
影响因子：
2.2
作者：
Gorlyn, Marianne;Keilp, John G.;Mann, J. John
通讯作者：
Mann, J. John