Smoking and Parkinson's disease. Search for a dose-response relationship.
Smoking and Parkinson's disease. Search for a dose-response relationship.
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吸烟与帕金森病。
作者：
L. Golbe;R. Cody;R. Duvoisin
我们检验了吸烟与帕金森病（PD）的负相关性来自吸烟对PD的直接药理学益处的假设。我们向联合帕金森基金会的32，000名成员邮寄了调查问卷，并寻找吸烟强度增加和PD强度降低之间的剂量反应效应的证据。在6006名受访者中，3693人符合我们的诊断标准。尽管将分析限制在混杂效应最小化的亚组中，但我们发现任何吸烟指标与PD严重程度指标之间均无显著相关性，并得出结论，吸烟可能对预防、延迟或改善PD无益处。
We tested the hypothesis that the inverse association of smoking and Parkinson's disease (PD) results from a direct pharmacologic benefit of smoking on PD. We mailed questionnaires to the 32,000 members of the United Parkinson Foundation and searched for evidence of a dose-response effect between increasing intensity of smoking and decreasing intensity of PD. Of the 6006 respondents, 3693 met our diagnostic criteria. Despite confining the analysis to subgroups where confounding effects would be minimized, we found no significant correlation between any measure of smoking and any measure of PD severity and conclude that smoking is probably not of benefit in preventing, delaying, or ameliorating PD.
DOI：
10.1002/mds.870090215
发表时间：
1982-07
期刊：
Journal of Neurology, Neurosurgery & Psychiatry
影响因子：
--
作者：
R. Mayeux;M. Tang;K. Marder;L. Cote;Y. Stern
通讯作者：
R. Mayeux;M. Tang;K. Marder;L. Cote;Y. Stern
影响因子：
158.5
作者：
BENOWITZ, NL;HALL, SM;OSMAN, AL
通讯作者：
OSMAN, AL