The central role of the gut microbiota in chronic inflammatory diseases.
The central role of the gut microbiota in chronic inflammatory diseases.
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DOI：
10.1155/2014/689492
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发表时间：
2014
影响因子：
4.1
通讯作者：
Martins Fdos S
中科院分区：
文献类型：
--
作者：
Ferreira CM;Vieira AT;Vinolo MA;Oliveira FA;Curi R;Martins Fdos S
共生菌群不断与免疫系统相互作用，教导免疫细胞对抗原作出反应。对小鼠的研究表明，对肠道微生物群的操纵可以改变宿主免疫细胞的稳态。此外，宏基因组测序分析揭示了患有炎症性肠病、哮喘和肥胖的患者肠道微生物群的改变。微生物群组成的扰动导致免疫反应缺陷和对共生微生物的耐受性受损。由于与某些炎症性疾病相关的微生物群组成的改变，一些策略，如益生菌的施用，饮食和抗生素的使用，已被用于预防或改善慢性炎症性疾病。这篇综述的目的是提出和讨论最近的证据表明肠道微生物群控制免疫系统功能和一些常见炎症性疾病的发生、发展和消退。
The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity. Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms. Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases. The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases.
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