Denial in methamphetamine users: Associations with cognition and functional connectivity in brain.
Denial in methamphetamine users: Associations with cognition and functional connectivity in brain.
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DOI：
10.1016/j.drugalcdep.2015.03.004
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发表时间：
2015-06-01
影响因子：
4.2
通讯作者：
London, Edythe D.
中科院分区：
文献类型：
--
作者：
Dean, Andy C.;Kohno, Milky;Morales, Angelica M.;Ghahremani, Dara G.;London, Edythe D.
尽管药物成瘾的有害后果，但患有药物使用障碍的个人否认有药物问题是很常见的。新出现的证据表明，由于神经认知功能障碍，一些吸毒者对自己的行为缺乏洞察力，但很少有研究探讨神经认知对否认的潜在贡献。本研究探讨了否认、认知绩效与脑功能连接的关系。参与者是58名非寻求治疗的甲基苯丙胺依赖参与者，他们完成了URICA沉思前量表，这是一种否认药物问题的自我报告措施，以及认知测试电池。一部分参与者（N=21）进行功能性MRI扫描，评估静息状态功能连接。鉴于文献表明喙前扣带回（rACC），前扣带回和楔前叶在自我意识中的作用，否认和静息状态连接之间的关系进行了测试，使用放置在这些地区的种子。结果显示，否认和整体认知能力得分之间存在负相关（p=0.001），这种影响尤其受到记忆和执行功能测试的影响。否认与rACC和额叶（中央前回，左腹内侧前额叶皮层，左眶额皮层），边缘系统（左杏仁核，左海马和左海马旁回），枕叶和小脑之间的连接强度呈负相关;楔前叶和中脑和小脑之间。前额叶连接与否认无关。这些发现表明，甲基苯丙胺使用者的否认与认知和神经表型有关，这可能会阻碍对他们行为的洞察力的发展。
Despite harmful consequences of drug addiction, it is common for individuals with substance use disorders to deny having problems with drugs. Emerging evidence suggests that some drug users lack insight into their behavior due to neurocognitive dysfunction, but little research has examined potential neurocognitive contributions to denial. This study explored the relationship between denial, cognitive performance and functional connectivity in brain. The participants were 58 non-treatment-seeking, methamphetamine-dependent participants who completed the URICA Precontemplation scale, a self-report measure of denial of drug problems warranting change, as well as a cognitive test battery. A subset of participants (N=21) had functional MRI scans assessing resting-state functional connectivity. Given literature indicating roles of the rostral anterior cingulate (rACC), anterior insula and precuneus in self-awareness, relationships between denial and resting-state connectivity were tested using seeds placed in these regions. The results revealed a negative relationship between denial and an overall cognitive battery score (p=0.001), the effect being driven particularly by performance on tests of memory and executive function. Denial was negatively associated with strength of connectivity between the rACC and regions of the frontal lobe (precentral gyri, left ventromedial prefrontal cortex, left orbitofrontal cortex), limbic system (left amygdala, left hippocampus and left parahippocampal gyrus), occipital lobes and cerebellum; and between the precuneus and the midbrain and cerebellum. Anterior insula connectivity was unrelated to denial. These findings suggest that denial by methamphetamine users is linked with a cognitive and neural phenotype that may impede the development of insight into their behavior.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1186/1747-597x-6-3
发表时间：
2011-02-14
期刊：
Substance abuse treatment, prevention, and policy
影响因子：
--
作者：
Kenny P;Harney A;Lee NK;Pennay A
通讯作者：
Pennay A
影响因子：
3.4
作者：
Blume, AW;Marlatt, GA;Schmaling, KB
通讯作者：
Schmaling, KB
影响因子：
7.6
作者：
Hester, Robert;Simoes-Franklin, Cristina;Garavan, Hugh
通讯作者：
Garavan, Hugh