Auditory cortical neurons are sensitive to static and continuously changing interaural phase cues.
Auditory cortical neurons are sensitive to static and continuously changing interaural phase cues.
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听觉皮层神经元对静态和连续变化的耳间相位线索敏感。
DOI：
10.1152/jn.1990.64.4.1247
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发表时间：
1990
影响因子：
2.5
通讯作者：
Brugge,JF
中科院分区：
文献类型：
--
作者：
Reale,RA;Brugge,JF
1.在120 ~ 2500 Hz刺激频率范围内，研究了麻醉猫初级听觉皮层单个神经元的耳间相位差（IPD）敏感性。对IPD敏感的43个AI细胞的最佳频率范围为190 - 2，400 Hz。2.当一对低频短纯音（仅在起始相位上彼此不同）被二分法呈现时，产生静态IPD。所得到的IPD敏感性曲线，其绘制的双耳信号诱发的放电的数量作为IPD的函数，是深度调制的圆形函数。分析IPD功能的平均向量长度（r）和平均耳间相位（phi）。相位灵敏度与最佳频率无关，但与刺激频率密切相关。无论BF或刺激频率内的兴奋性反应区的大多数细胞发射最大时，同侧的音调滞后于对侧的信号和发射最少时，这种interaural相位关系被逆转。3.通过向两只耳朵传递频率略有不同的3秒音调，产生双耳节拍，研究了对连续变化IPD的敏感性。大约26%的细胞表现出对IPD静态变化的敏感性，也表现出对由这种双耳音调组合产生的动态变化的IPD的敏感性。放电是高度周期性的，并且与双耳节拍周期的特定相位紧密同步。高同步性可以归因于这样的事实，即皮质神经元通常对兴奋性刺激的反应只有一个单一的尖峰，该尖峰通常精确地定时到刺激开始。一个周期的直方图，双耳拍频（FB）上分仓，产生了一个等效的IPD灵敏度函数动态变化的耳间相位。对于静态和连续变化的耳间相位敏感的神经元，它们的静态（φ s）和动态（φ d）平均耳间相位之间有很好的对应关系。4.所有的细胞响应于一个动态变化的刺激表现出平均耳间相位和拍频之间的线性关系。大多数细胞对双耳节拍的反应都一样好，不管相位变化的初始方向如何。对于一个固定的持续时间的刺激，并在相对较低的fb，诱发的尖峰的数量增加，增加fb，反映了有效的刺激周期的数量增加。在较高的fb下，AI神经元无法遵循在3 s刺激期间最有效相重复的速率。（400字处截断摘要）
1. The interaural-phase-difference (IPD) sensitivity of single neurons in the primary auditory (AI) cortex of the anesthetized cat was studied at stimulus frequencies ranging from 120 to 2,500 Hz. Best frequencies of the 43 AI cells sensitive to IPD ranged from 190 to 2,400 Hz. 2. A static IPD was produced when a pair of low-frequency tone bursts, differing from one another only in starting phase, were presented dichotically. The resulting IPD-sensitivity curves, which plot the number of discharges evoked by the binaural signal as a function of IPD, were deeply modulated circular functions. IPD functions were analyzed for their mean vector length (r) and mean interaural phase (phi). Phase sensitivity was relatively independent of best frequency (BF) but highly dependent on stimulus frequency. Regardless of BF or stimulus frequency within the excitatory response area the majority of cells fired maximally when the ipsilateral tone lagged the contralateral signal and fired least when this interaural-phase relationship was reversed. 3. Sensitivity to continuously changing IPD was studied by delivering to the two ears 3-s tones that differed slightly in frequency, resulting in a binaural beat. Approximately 26% of the cells that showed a sensitivity to static changes in IPD also showed a sensitivity to dynamically changing IPD created by this binaural tonal combination. The discharges were highly periodic and tightly synchronized to a particular phase of the binaural beat cycle. High synchrony can be attributed to the fact that cortical neurons typically respond to an excitatory stimulus with but a single spike that is often precisely timed to stimulus onset. A period histogram, binned on the binaural beat frequency (fb), produced an equivalent IPD-sensitivity function for dynamically changing interaural phase. For neurons sensitive to both static and continuously changing interaural phase there was good correspondence between their static (phi s) and dynamic (phi d) mean interaural phases. 4. All cells responding to a dynamically changing stimulus exhibited a linear relationship between mean interaural phase and beat frequency. Most cells responded equally well to binaural beats regardless of the initial direction of phase change. For a fixed duration stimulus, and at relatively low fb, the number of spikes evoked increased with increasing fb, reflecting the increasing number of effective stimulus cycles. At higher fb, AI neurons were unable to follow the rate at which the most effective phase repeated itself during the 3 s of stimulation.(ABSTRACT TRUNCATED AT 400 WORDS)
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影响因子：
2.5
作者：
ROSE, JE;GROSS, NB;HIND, JE
通讯作者：
HIND, JE
影响因子：
2.5
作者：
BRUGGE, JF;MERZENICH, MM
通讯作者：
MERZENICH, MM
耳间时间差异：关于声音定位的神经生理学的影响。
DOI：
10.1121/1.385196
发表时间：
1980
期刊：
The Journal of the Acoustical Society of America
影响因子：
--
作者：
Roth,GL;Kochhar,RK;Hind,JE
通讯作者：
Hind,JE
声音定位的神经生理学进展。
影响因子：
24.8
作者：
Phillips,DP;Brugge,JF
通讯作者：
Brugge,JF
噪声刺激的耳间时间延迟对猫下丘低频细胞的影响。
影响因子：
2.5
作者：
Yin,TC;Chan,JC;Irvine,DR
通讯作者：
Irvine,DR