Novel sound exposure drives dynamic changes in auditory lateralization that are associated with perceptual learning in zebra finches.
Novel sound exposure drives dynamic changes in auditory lateralization that are associated with perceptual learning in zebra finches.
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DOI：
10.1038/s42003-023-05567-7
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发表时间：
2023-11-27
影响因子：
5.9
通讯作者：
Vicario, David S.
中科院分区：
文献类型：
--
作者：
Cataldo, Basilio Furest;Yang, Lillian;Cabezas, Bryan;Ovetsky, Jonathan;Vicario, David S.
鸣禽为成年听觉皮层的可塑性提供了一个模型，作为一种与人类听觉处理相似的近期经验的功能。至于人类的语言处理，鸣禽的高级听觉皮层（尾侧皮层，NCM）的活动是侧向的，用于处理复杂的发声声音。然而，在暴露于新的异种（金丝雀）声环境4-9天的斑马雀中，典型的右偏化模式被逆转。我们现在报道，在长时间（长达21天）被动暴露于新的异种环境的鸟类中，硬膜外听觉电位的右偏侧模式首先短暂逆转，然后返回到典型模式。使用急性，双侧多单位电生理学，我们证实这种动态模式发生在NCM。此外，长时间暴露增强了对异特异性刺激的辨别。我们的结论是，侧化在功能上是不稳定的，当被新的感官体验参与时，有助于对可能与动物行为学相关的新刺激的区分。未来的研究将试图确定：(1)在同一生物体中，每一次新的挑战都会重复出现由新的感官体验引起的侧化过程的动态；(2)动态模式扩展到其他皮层、丘脑或中脑结构；(3)这种现象在感觉模式中普遍化。斑马雀暴露在新的金丝雀环境中的听觉反应显示出典型的大脑侧化的短暂逆转，同时对金丝雀叫声的辨别能力也有所提高，从而表明侧化不是固定的，而是动态调节的。
Songbirds provide a model for adult plasticity in the auditory cortex as a function of recent experience due to parallels with human auditory processing. As for speech processing in humans, activity in songbirds’ higher auditory cortex (caudomedial nidopallium, NCM) is lateralized for complex vocalization sounds. However, in Zebra finches exposed to a novel heterospecific (canary) acoustic environment for 4–9 days, the typical pattern of right-lateralization is reversed. We now report that, in birds passively exposed to a novel heterospecific environment for extended periods (up to 21 days), the right-lateralized pattern of epidural auditory potentials first reverses transiently then returns to the typical pattern. Using acute, bilateral multi-unit electrophysiology, we confirm that this dynamic pattern occurs in NCM. Furthermore, extended exposure enhances discrimination for heterospecific stimuli. We conclude that lateralization is functionally labile and, when engaged by novel sensory experience, contributes to discrimination of novel stimuli that may be ethologically relevant. Future studies seek to determine whether, (1) the dynamicity of lateralized processes engaged by novel sensory experiences recurs with every novel challenge in the same organism; (2) the dynamic pattern extends to other cortical, thalamic or midbrain structures; and (3) the phenomenon generalizes across sensory modalities. Auditory responses in zebra finches exposed to a novel canary environment show a surprising transient reversal of typical brain lateralization together with improved discrimination of canary vocalizations, thereby suggesting that lateralization is not fixed, but dynamically regulated.
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影响因子：
3
作者：
Maul, Kristen K.;Voss, Henning U.;Parra, Lucas C.;Salgado-Commissariat, Delanthi;Ballon, Douglas;Tchernichovski, Ofer;Helekar, Santosh A.
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Helekar, Santosh A.
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影响因子：
2.5
作者：
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通讯作者：
Nordby, JC
影响因子：
1.4
作者：
DOOLING, RJ;BROWN, SD;OKANOYA, K
通讯作者：
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