COVID-19 Pandemic and Its Impact on Perinatal Outcomes between Symptomatic and Asymptomatic Women.
COVID-19 Pandemic and Its Impact on Perinatal Outcomes between Symptomatic and Asymptomatic Women.
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DOI：
10.1155/2022/1756266
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发表时间：
2022
影响因子：
1.9
通讯作者：
Alkhalifa, Khalid
中科院分区：
文献类型：
--
作者：
Babic, Inas;Alsomali, Faten;Aljuhani, Sana;Baeissa, Sahar;Alhabib, Inam;AlAhmari, Ebtisam;Omer, Magdy;Alkhalifa, Khalid
2019冠状病毒病（COVID-19）在全球孕妇中不断增加。其对孕产妇、胎儿和新生儿健康的影响在已发表的文献中仍然很少。由于已经为所有需要住院的妇女建立了常规的COVID-19产前筛查，目前尚不清楚有症状的妇女是否比没有症状的妇女的妊娠结局更差。我们的目的是分析有症状和无症状的妇女之间的围产期结局收住我们的中心。材料和方法。进行了为期14个月的单中心回顾性队列研究。所有严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）逆转录-聚合酶链反应（RT-PCR）检测结果阳性的孕妇均入组，根据是否有症状分为两组，分析其围产儿结局。主要结局是胎儿、新生儿和母体的复合不良结局及其在研究组之间的比较。结果在209名COVID-19阳性孕妇中，62名（30%）出现一种或多种感染相关症状。与无症状女性相比，有症状女性年龄较大，多产，携带≥1种共病疾病，并在较早的胎龄获得感染（分别为44% vs. 28%; 82% vs. 69%; 28% vs. 16%; 34 vs. 36周）（p < 0.05）。有症状组的产妇复合不良结局更高，并且显示一种或多种结局、阳性胸部放射学检查结果、需要住院补充氧气或产妇死亡（8% vs. 0.7%）（p < 0.05）。有症状和无症状妇女之间的复合胎儿和新生儿不良结局，如流产、胎儿或新生儿死亡、进入新生儿重症监护室和新生儿COVID-19感染，无统计学意义（p > 0.05）。结论有症状的孕妇感染COVID-19可能会带来更高的不良孕产妇结局风险。这可能与他们的高龄和合并症有关。母体感染相关症状本身可能不会增加胎儿或新生儿不良结局的风险。
Coronavirus disease 2019 (COVID-19) has been increasing among pregnant women worldwide. Its impact on maternal, fetal, and neonatal health is still scarce in the published literature. As a routine COVID-19 prenatal screening has been established for all women requiring hospitalization, it is not clear whether symptomatic women carry worse pregnancy outcomes than those without symptoms. We aimed to analyze perinatal outcomes between symptomatic and asymptomatic women admitted to our center. Materials and Methods. A single-center retrospective cohort study was conducted for fourteen months. All pregnant women with positive reverse transcriptase-polymerase chain reaction (RT-PCR) test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were enrolled, and their perinatal outcomes were analyzed in two groups based on whether they were symptomatic or not. The primary outcomes were composite adverse fetal, neonatal, and maternal outcomes and their comparison between study groups. Results. Out of 209 included COVID-19 positive pregnant women, 62 (30%) presented with one or more infection-related symptoms. Symptomatic women were older, multiparous, carried ≥1 comorbid condition, and attained infection at earlier gestational age (44% vs. 28%; 82% vs. 69%; 28% vs. 16%; and 34 vs. 36 weeks, respectively) (p < 0.05), when compared to asymptomatic women, respectively. Maternal composite adverse outcomes were higher in the symptomatic group and showed either one or more outcomes, positive chest radiological findings, requiring hospitalization with oxygen supplementation, or maternal death (8% vs. 0.7%) (p < 0.05). Composite fetal and neonatal adverse outcomes such as miscarriage, fetal or neonatal death, admission to neonatal intensive care unit, and neonatal COVID-19 infection were not statistically significant (p > 0.05) between symptomatic and asymptomatic women. Conclusion. COVID-19 infection among symptomatic pregnant women may carry a higher risk for adverse maternal outcomes. It may be associated with their advanced age and comorbid conditions. Maternal infection-associated symptoms per se likely do not pose an increased risk for adverse fetal or neonatal outcomes.
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影响因子：
4.6
作者：
Vouga M;Favre G;Martinez-Perez O;Pomar L;Acebal LF;Abascal-Saiz A;Hernandez MRV;Hcini N;Lambert V;Carles G;Sichitiu J;Salomon L;Stirnemann J;Ville Y;de Tejada BM;Goncé A;Hawkins-Villarreal A;Castillo K;Solsona EG;Trigo L;Cleary B;Geary M;Bartels H;Al-Kharouf F;Malone F;Higgins M;Keating N;Knowles S;Poncelet C;Ribeiro-do-Valle CC;Surita F;Dantas-Silva A;Borrelli C;Luz AG;Fuenzalida J;Carvajal J;Canales MG;Hernandez O;Grechukhina O;Ko AI;Reddy U;Figueiredo R;Moucho M;Pinto PV;De Luca C;De Santis M;de Campos DA;Martins I;Garabedian C;Subtil D;Bohrer B;Da Rocha Oppermann ML;Wender MCO;Schuler-Faccini L;Sanseverino MTV;Giugliani C;Friedrich L;Scherer MH;Mottet N;Ducarme G;Pelerin H;Moreau C;Breton B;Quibel T;Rozenberg P;Giannoni E;Granado C;Monod C;Mueller D;Hoesli I;Bassler D;Heldstab S;Kölble NO;Sentilhes L;Charvet M;Deprest J;Richter J;Van der Veeken L;Eggel-Hort B;Plantefeve G;Derouich M;Calvache AJN;Lopez-Giron MC;Burgos-Luna JM;Escobar-Vidarte MF;Hecher K;Tallarek AC;Hadar E;Haratz KK;Amikam U;Malinger G;Maymon R;Yogev Y;Schäffer L;Toussaint A;Rossier MC;De Sa RAM;Grawe C;Aebi-Popp K;Radan AP;Raio L;Surbek D;Böckenhoff P;Strizek B;Kaufmann M;Bloch A;Boulvain M;Johann S;Heldstab SA;Bernasconi MT;Grant G;Feki A;Brochut AM;Giral M;Sedille L;Papadia A;Brugger RC;Weber B;Fischer T;Kahlert C;Saines KN;Cambou M;Kanellos P;Chen X;Yin M;Haessig A;Ackermann S;Baud D;Panchaud A
通讯作者：
Panchaud A
DOI：
10.1016/s2214-109x(21)00079-6
发表时间：
2021-06
期刊：
The Lancet. Global health
影响因子：
--
作者：
Chmielewska B;Barratt I;Townsend R;Kalafat E;van der Meulen J;Gurol-Urganci I;O'Brien P;Morris E;Draycott T;Thangaratinam S;Le Doare K;Ladhani S;von Dadelszen P;Magee L;Khalil A
通讯作者：
Khalil A
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
DOI：
10.1016/j.ajogmf.2020.100118
发表时间：
2020-05-01
影响因子：
6.3
作者：
Breslin, Noelle;Baptiste, Caitlin;Goffman, Dena
通讯作者：
Goffman, Dena
影响因子：
26.1
作者：
Villar J;Ariff S;Gunier RB;Thiruvengadam R;Rauch S;Kholin A;Roggero P;Prefumo F;do Vale MS;Cardona-Perez JA;Maiz N;Cetin I;Savasi V;Deruelle P;Easter SR;Sichitiu J;Soto Conti CP;Ernawati E;Mhatre M;Teji JS;Liu B;Capelli C;Oberto M;Salazar L;Gravett MG;Cavoretto PI;Nachinab VB;Galadanci H;Oros D;Ayede AI;Sentilhes L;Bako B;Savorani M;Cena H;García-May PK;Etuk S;Casale R;Abd-Elsalam S;Ikenoue S;Aminu MB;Vecciarelli C;Duro EA;Usman MA;John-Akinola Y;Nieto R;Ferrazi E;Bhutta ZA;Langer A;Kennedy SH;Papageorghiou AT
通讯作者：
Papageorghiou AT