Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry.
Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry.
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DOI：
10.1038/ajg.2009.543
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Furuta GT
中科院分区：
文献类型：
--
作者：
Nurko S;Rosen R;Furuta GT
嗜酸性粒细胞性食管炎（EoE）患者吞咽困难的病理生理尚不清楚，但可能与食管运动功能异常有关。在固定式食管测压时很少出现症状，因此很难建立症状与运动事件之间的联系。为了评估EoE患儿的食管运动功能，采用固定测压法和动态延长食管测压ph法（PEMP）对EoE患儿进行了食管测压ph法（PEMP），并与对照组和GERD患儿进行了比较。当食道收缩幅度和收缩范围正常时，认为是有效的蠕动。结果以mean±S.E.表示。17例EoE患者，13例GERD患者和11例对照组进行了研究。数值以平均值±se表示。静止测压法发现41%的EoE患儿的蠕动异常。PEMP期间,儿童数量的增加与EoE孤立(16.7±3.8 vs 9.5±1.6 vs 6.5±1.1;p < 0.03)和高振幅收缩(4.1±1.2 vs 1.8±0.8 vs 0.1±0.1;p < 0.03),和更多的%无效的蠕动在禁食(70.5% vs 57.8%±3.0±2.5 vs 53.8%±1.9;p < 0.05),在餐(68.4±3.4 vs 55.3±2.8 vs 48.1±2.8;p < 0.05)相比,儿童GERD和控制。13例EoE患者出现21次吞咽困难发作，均伴有运动功能异常。PEMP可以检测出EoE患儿的无效蠕动。在EoE患儿中观察到的症状可能与食管运动功能障碍有关。
The pathophysiology of dysphagia in patients with eosinophilic esophagitis (EoE) is unknown, but may be related to abnormal esophageal motor function. Symptoms rarely occur during stationary esophageal manometry so it has been difficult to establish an association between symptoms and motor events. To evaluate esophageal motor function in children with EoE with the use of stationary manometry and ambulatory prolonged esophageal manometry and pH-metry (PEMP) PEMP was performed in children with EoE, compared with controls and children with GERD. Effective peristalsis was considered when the esophageal contractions had a normal amplitude and propagation. Results expressed as mean ± S.E. Seventeen patients with EoE, 13 with GERD and 11 controls were studied. Values are expressed as mean ± se. Stationary manometry identified abnormal peristalsis in 41% of children with EoE. During PEMP, children with EoE had an increased number of isolated (16.7 ± 3.8 vs 9.5 ± 1.6 vs 6.5 ± 1.1 ; p< 0.03) and high amplitude contractions (4.1 ± 1.2 vs 1.8 ±0.8 vs 0.1 ± 0.1; p< 0.03), and more % ineffective peristalsis both during fasting (70.5% ± 2.5 vs 57.8% ± 3.0 vs 53.8% ± 1.9; p <0.05) and during meals (68.4 ± 3.4 vs 55.3 ± 2.8 vs 48.1 ± 2.8; p < 0.05) when compared with children with GERD and controls. Thirteen patients with EoE experienced 21 episodes of dysphagia and all correlated with simultaneous abnormal motor function. PEMP allowed the detection of ineffective peristalsis in children with EoE. Symptoms observed in children with EoE may be related to esophageal motor dysfunction.
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