Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence
Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence
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1 型单纯疱疹病毒对人类免疫缺陷病毒长末端重复序列的激活与与 NF-κ B/核心增强子序列结合的核因子的诱导有关
作者：
J. Gimble;E. Duh;J. Ostrove;H. Gendelman;E E Max;A. B. Rabson
以前已经表明，单纯疱疹病毒1型（HSV-1）感染HeLa细胞导致由人免疫缺陷病毒（HIV）长末端重复序列（LTR）指导的基因表达增强。这种效应可能是由蛋白质与LTR的相互作用介导的。我们已经使用了两种不同的DNA-蛋白质相互作用的测定来研究HSV诱导的HIV LTR的激活。HIV LTR的激活与包括NF-κ B/核心增强子和Sp1结合序列的区域中的LTR序列的蛋白结合增加相关，如通过核酸外切酶保护测定监测的。凝胶阻滞试验表明，HSV-1感染导致诱导与NF-κ B/核心增强子序列结合的核因子。除了HIV LTR的激活，HSV对NF-κ B活性的诱导对于疱疹病毒感染期间HSV基因表达的调节可能是重要的。
It has been previously shown that herpes simplex virus type 1 (HSV-1) infection of HeLa cells results in augmentation of gene expression directed by the human immunodeficiency virus (HIV) long terminal repeat (LTR). This effect is presumably mediated by protein interactions with the LTR. We have used two different assays of DNA-protein interactions to study the HSV-induced activation of the HIV LTR. Activation of the HIV LTR is associated with increased protein binding to LTR sequences in a region including the NF-kappa B/core enhancer and the Sp1 binding sequences as monitored by an exonuclease protection assay. Gel retardation assays demonstrated that HSV-1 infection resulted in the induction of a nuclear factor(s) that binds to the NF-kappa B/core enhancer sequence. In addition to the activation of the HIV LTR, HSV induction of NF-kappa B activity may be important for the regulation of HSV gene expression during a herpesvirus infection.
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影响因子：
56.9
作者：
Gary J. Nabel;Stephen A. Rice;D. Knipe;D. Baltimore
通讯作者：
Gary J. Nabel;Stephen A. Rice;D. Knipe;D. Baltimore
影响因子：
11.4
作者：
GARCIA, JA;WU, FK;GAYNOR, RB
通讯作者：
GAYNOR, RB
人类免疫缺陷病毒突变分析：orf-B区下调病毒复制。
DOI：
10.1073/pnas.84.5.1434
发表时间：
1987
影响因子：
11.1
作者：
Luciw,PA;Cheng-Mayer,C;Levy,JA
通讯作者：
Levy,JA
影响因子：
56.9
作者：
C. M. Wright;B. Felber;H. Paskalis;G. Pavlakis
通讯作者：
C. M. Wright;B. Felber;H. Paskalis;G. Pavlakis
Epstein-Barr 病毒立即早期基因产物反式激活人类免疫缺陷病毒长末端重复序列的基因表达。
DOI：
10.1073/pnas.85.5.1652
发表时间：
1988
影响因子：
11.1
作者：
Kenney,S;Kamine,J;Markovitz,D;Fenrick,R;Pagano,J
通讯作者：
Pagano,J