The endoscopic prediction model of simple endoscopic score for Crohn's disease (SES-CD) as an effective predictor of intestinal obstruction in Crohn's disease: A multicenter long-term follow-up study.
The endoscopic prediction model of simple endoscopic score for Crohn's disease (SES-CD) as an effective predictor of intestinal obstruction in Crohn's disease: A multicenter long-term follow-up study.
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克罗恩病简单内镜评分（SES-CD）的内镜预测模型作为克罗恩病肠梗阻的有效预测因子：一项多中心长期随访研究
DOI：
10.3389/fsurg.2022.984029
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发表时间：
2022
影响因子：
1.8
通讯作者：
Du, Peng
中科院分区：
文献类型：
--
作者：
Xu, Weimin;Hua, Zhebin;Wang, Yaosheng;Gu, Yubei;Zhong, Jie;Cui, Long;Du, Peng
关键词：
克罗恩病简易内镜评分（SES-CD）是一种广泛应用的评价临床和内镜活动性的指标。然而，SES-CD与克罗恩病（CD）肠梗阻的相关性和预测价值仍不清楚。我们的目的是建立SES-CD的最佳截断指标，用于早期临床干预和随后预防CD肠梗阻。方法回顾性收集2016年1月至2022年1月在我院接受评估的CD患者的资料。分析中使用的SES-CD和克罗恩病活动指数评分表明住院后首次临床和结肠镜检查评价的结果。主要结局是入院和随访期间肠梗阻的发生率。结果共纳入248例患者，中位随访时间为2年[四分位距：1.0-4.0]，其中28.2%发生肠梗阻。SES-CD评分8分是最有意义的阈值评价，SES-CD ≥8分的受试者工作特征曲线下面积最大（0.705），预测肠梗阻的敏感性为52.9%，特异性为88.2%。此外，SES-CD ≥8是肠梗阻的最大危险因素（比值比：7.731; 95%置信区间：3.901-15.322; p < 0.001），并显著降低了总体无肠梗阻生存率（p < 0.001）。结论SES-CD内镜预测模型可作为CD患者肠梗阻的有效预测指标。对于SES-CD评分≥8的患者，应考虑更频繁的随访和结肠镜监测，以防止肠梗阻的发生。
Background The simple endoscopic score for Crohn's disease (SES-CD) is a widely used index to evaluate clinical and endoscopic activity. However, the association and predictive value of SES-CD for intestinal obstruction in Crohn's disease (CD) remains unclear. We aimed to establish the best cut-off indicators of SES-CD for early clinical intervention and subsequent prevention of intestinal obstruction in CD. Methods Data on patients with CD evaluated at our institute from January 2016 to January 2022 were retrospectively collected. The SES-CD and Crohn's Disease Activity Index scores used in the analysis indicated the results of the first clinical and colonoscopy evaluations after hospitalization. The primary outcome was the occurrence of intestinal obstruction during admission and follow-up. Results A total of 248 patients with a median follow-up time of 2 years [interquartile range: 1.0–4.0] were enrolled, of which 28.2% developed intestinal obstruction. An SES-CD score of 8 was the most significant threshold evaluation, and SES-CD ≥8 had the largest area under the receiver operating characteristic curve (0.705), with a sensitivity of 52.9% and specificity of 88.2% in predicting intestinal obstruction. Furthermore, SES-CD ≥8 had the greatest risk factor for intestinal obstruction (odds ratio: 7.731; 95% confidence interval: 3.901–15.322; p < 0.001) and significantly decreased the overall intestinal obstruction-free survival (p < 0.001). Conclusion The SES-CD endoscopic prediction model could be an effective predictor of intestinal obstruction in patients with CD. More frequent follow-up and colonoscopic surveillance should be considered in patients with SES-CD score ≥8 to prevent the development of intestinal obstruction.
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影响因子：
29.4
作者：
Danese, Silvio;Sandborn, William J.;Feagan, Brian G.
通讯作者：
Feagan, Brian G.
影响因子：
4.9
作者：
Sipponen, Taina;Nuutinen, Hannu;Farkkila, Martti
通讯作者：
Farkkila, Martti
溃疡性结肠炎继发肠外表现的临床结局及危险因素：多中心长期随访回顾性研究结果
影响因子：
2.7
作者：
Xu, Weimin;Ou, Weijun;Du, Peng
通讯作者：
Du, Peng
影响因子：
29.4
作者：
Thia KT;Sandborn WJ;Harmsen WS;Zinsmeister AR;Loftus EV Jr
通讯作者：
Loftus EV Jr
影响因子：
7.7
作者：
Daperno, M;D'Haens, G;Rutgeerts, P
通讯作者：
Rutgeerts, P