The Metabolic Syndrome Is Associated With Lower Cognitive Performance and Reduced White Matter Integrity in Midlife: The CARDIA Study.
The Metabolic Syndrome Is Associated With Lower Cognitive Performance and Reduced White Matter Integrity in Midlife: The CARDIA Study.
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DOI：
10.3389/fnins.2022.942743
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发表时间：
2022
影响因子：
4.3
通讯作者：
Yaffe, Kristine
中科院分区：
文献类型：
--
作者：
Dintica, Christina S.;Hoang, Tina;Allen, Norrina;Sidney, Stephen;Yaffe, Kristine
心血管疾病的危险因素在大脑衰老中起着关键作用。代谢综合征（MetS）是一系列心血管危险因素，与老年认知能力较差有关;然而，目前尚不清楚它是否与生命早期的大脑健康有关。我们在前瞻性研究中调查了MetS（n = 534，18.5%）与无MetS（n = 2，346，81.5%）与中年认知的相关性，年轻人冠状动脉风险发展（CARDIA）。在中年（平均年龄50岁），代谢综合征是根据国家胆固醇教育计划指南定义的。在5年随访时，进行认知成套测试，包括处理速度（数字符号替代测试，DSST）、执行功能（Stroop测试）、言语记忆（Rey听觉言语学习测试，RAVLT）、言语流畅性（类别和字母流畅性）和整体认知功能（蒙特利尔认知评估，莫卡）测试。一个子样本（n = 453）进行了脑MRI。代谢综合征患者在语言流畅性、处理速度、执行功能和言语记忆测试中表现较差（p < 0.05），但在整体认知方面没有表现。MetS还与下额叶、顶叶、颞叶和总白色物质完整性相关（p < 0.05），如分数各向异性评估。MetS与中年时的认知能力降低和大脑微结构改变有关，这表明MetS应该在生命早期就被靶向，以防止不良的大脑和认知结果。
Cardiovascular disease risk factors play a critical role in brain aging. The metabolic syndrome (MetS), a constellation of cardiovascular risk factors, has been associated with poorer cognition in old age; however, it is unclear if it is connected to brain health earlier in life. We investigated the association of MetS (n = 534, 18.5%) vs. no MetS (n = 2,346, 81.5%) with cognition in midlife within the prospective study, Coronary Artery Risk Development in Young Adults (CARDIA). At midlife (mean age 50), MetS was defined using National Cholesterol Education Program guidelines. At the 5-year follow-up, a cognitive battery was administered including tests of processing speed (Digit Symbol Substitution Test, DSST), executive function (the Stroop Test), verbal memory (Rey Auditory Verbal Learning Test, RAVLT), verbal fluency (category and letter fluency), and global cognitive function (Montreal Cognitive Assessment, MoCA). A sub-sample (n = 453) underwent brain MRI. Participants with MetS had worse performance on tests of verbal fluency, processing speed, executive function, and verbal memory (p < 0.05), but not on global cognition. MetS was also associated with lower frontal, parietal, temporal, and total white matter integrity (p < 0.05), as assessed with fractional anisotropy. MetS is associated with lower cognition and microstructural brain alterations already at midlife, suggesting that MetS should be targeted earlier in life in order to prevent adverse brain and cognitive outcomes.
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