Neuropsychological effects of low-level manganese exposure in welders.
Neuropsychological effects of low-level manganese exposure in welders.
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DOI：
10.1016/j.neuro.2010.12.014
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发表时间：
2011-03
期刊：
影响因子：
3.4
通讯作者：
Weisskopf MG
中科院分区：
文献类型：
--
作者：
Laohaudomchok W;Lin X;Herrick RF;Fang SC;Cavallari JM;Shrairman R;Landau A;Christiani DC;Weisskopf MG
虽然高锰（Mn）暴露在职业环境中的神经心理影响是众所周知的，但较低水平暴露的影响却鲜为人知。在这项研究中，我们调查了46名男性焊工（平均年龄= 37.4,sd = 11.7岁）低水平职业性锰暴露对神经心理的影响。每个焊工过去12个月的累积锰暴露指数（Mn- cei）和总工作历史锰暴露是基于空气锰测量和工作历史构建的。研究了这些暴露指数与认知、运动控制和心理测试表现之间的关系。此外，在一组在轮班前后完成测试的焊工（n=24）中，我们研究了通过个人监测评估的交叉轮班Mn暴露与测试分数的急性变化之间的关系。与其他类似研究相比，本研究中的锰暴露量（中位数= 12.9 μg/m3）要低得多。总Mn-CEI的增加与连续表现测试反应时间的减慢（CPT, p<0.01）以及情绪状态谱几个量表（POMS，困惑，疲倦，疲倦和精力充沛的复合，p≤0.03）的情绪恶化显著相关。在过去的12个月内，Mn-CEI的增加与悲伤、紧张和困惑POMS量表上更差的情绪显著相关（均p≤0.03），与更差的CPT表现的关联接近显著（p=0.10）。在一个工作日中，较高的锰暴露与全天CPT测试的较差表现（p=0.06）以及在工作班次中精细运动控制的下降（p=0.04）有关，调整了年龄和两个测试之间的时间。我们的研究表明，即使在相对较低的锰暴露水平下，神经心理效应也可能表现在注意力、情绪和精细运动控制方面。
While the neuropsychological effects of high manganese (Mn) exposure in occupational settings are well known, the effects of lower levels of exposure are less understood. In this study, we investigated the neuropsychological effects of lower level occupational Mn exposure in 46 male welders (mean age = 37.4, sd = 11.7 years). Each welders’ cumulative Mn exposure indices (Mn-CEI) for the past 12 months and total work history Mn exposure were constructed based on air Mn measurements and work histories. The association between these exposure indices and performance on cognitive, motor control, and psychological tests was examined. In addition, among a subset of welders (n=24) who completed the tests both before and after a work shift, we examined the association between cross-shift Mn exposure assessed from personal monitoring and acute changes in test scores. Mn exposures in this study (median = 12.9 μg/m3) were much lower, as compared to those observed in other similar studies. Increasing total Mn-CEI was significantly associated with slower reaction time on the continuous performance test (CPT; p<0.01), as well as worse mood for several scales on the Profile of Mood States (POMS; confused, tired, and a composite of tired and energetic, all p≤0.03). Increasing Mn-CEI over the previous 12 months was significantly associated with worse mood on the sad, tense, and confused POMS scales (all p≤0.03) and the association with worse CPT performance approached significance (p=0.10). Higher Mn exposure over the course of a workday was associated with worse performance on the CPT test across the day (p=0.06) as well as declines in fine motor control over the work-shift (p=0.04), adjusting for age and time between the 2 tests. Our study suggests that even at relatively low Mn exposure levels neuropsychological effects may manifest particularly with respect to attention, mood, and fine motor control.
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1080/15459624.2010.485262
发表时间：
2010-01-01
影响因子：
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作者：
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通讯作者：
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DOI：
10.1179/oeh.2003.9.2.153
发表时间：
2003-04-01
影响因子：
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作者：
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通讯作者：
Nassetta, WJ