Peripheral signals mediate the beneficial effects of gastric surgery in obesity.
Peripheral signals mediate the beneficial effects of gastric surgery in obesity.
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DOI：
10.1155/2015/560938
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发表时间：
2015
影响因子：
2
通讯作者：
Seoane LM
中科院分区：
文献类型：
--
作者：
Barja-Fernández S;Folgueira C;Castelao C;Leis R;Casanueva FF;Seoane LM
如今，肥胖在工业化国家和发展中国家都是一个公共健康问题。除胃手术外，其他治疗肥胖的方法都不太成功。尽管胃肠道激素产生模式的改变似乎是产生有益效果的原因，但实现这一过程的机制尚不清楚。胃肠道作为一种内分泌器官，在中枢水平上通过调节30多种信号来调节食物摄入和体重，从而对与营养状况有关的各种刺激作出反应。一些胃源性信号的产生已被证明在肥胖中发生改变（胃饥饿素、CCK和GLP-1）。事实上，减肥手术改变了胃肠道和脂肪组织外周信号的产生，而不是肠道微生物群的组成。本文将对肥胖中主要外周信号的改变及其在减肥手术后的改变进行综述。
Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in the pattern of gastrointestinal hormones production appear to be responsible for the beneficial effect. The gastrointestinal tract has emerged in the last time as an endocrine organ in charge of response to the different stimulus related to nutritional status by the modulation of more than 30 signals acting at central level to modulate food intake and body weight. The production of some of these gastric derived signals has been proved to be altered in obesity (ghrelin, CCK, and GLP-1). In fact, bariatric surgery modifies the production of both gastrointestinal and adipose tissue peripheral signals beyond the gut microbiota composition. Through this paper the main peripheral signals altered in obesity will be reviewed together with their modifications after bariatric surgery.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
--
作者：
Adamska E;Ostrowska L;Górska M;Krętowski A
通讯作者：
Krętowski A
影响因子：
2.9
作者：
BREAUX, CW
通讯作者：
BREAUX, CW
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
8.1
作者：
Blüher M
通讯作者：
Blüher M