Interfraction liver shape variability and impact on GTV position during liver stereotactic radiotherapy using abdominal compression.
Interfraction liver shape variability and impact on GTV position during liver stereotactic radiotherapy using abdominal compression.
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DOI：
10.1016/j.ijrobp.2010.08.003
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发表时间：
2011-07-01
影响因子：
7
通讯作者：
Brock, Kristy K.
中科院分区：
文献类型：
--
作者：
Eccles, Cynthia L.;Dawson, Laura A.;Moseley, Joanne L.;Brock, Kristy K.
对于接受肝脏立体定向全身放射治疗(SBRT)的患者，腹部按压可以减少器官运动，日常图像引导可以减少设置误差。受压下肝脏形状的重复性可能会影响治疗的准确性。本研究的目的是测量在从千伏(千伏)锥形束计算机断层扫描(CBCT)到计划计算机断层扫描(CT)的最佳匹配的刚性肝到肝的配准后，受压下肝脏形状的内部变异性及其对大体肿瘤体积(GTV)位置的影响。可评估的患者在研究伦理委员会批准的腹部按压的SBRT六分数研究中接受治疗。在治疗前采集千伏CBCT扫描，并脱机重建为呼吸分类CBCT扫描。从呼气期CBCT扫描到呼气计划CT扫描，都进行了手动严格的肝对肝登记。利用内部开发的基于有限元模型的可变形配准(MORFEUS)，将每个CBCT肝脏轮廓、输出，并与计划CT扫描的空间差异进行比较。我们评估了16名患者的83次CBCT扫描，共30个GTV。变形大于3 mm的肝脏平均体积为21.7%。剔除1个异常值，单个患者变形大于3 mm的最大体积为36.3%。在所有患者中，左右(LR)、前后(AP)和上下方向的绝对最大变形分别为10.5 mm(SD，2.2)、12.9 mm(SD，3.6)和5.6 mm(SD，2.7)。使用质心位移对GTV的绝对平均预测影响在左右、前后和上下方向上分别为0.09 mm(SD，0.13)、0.13 mm(SD，0.18)和0.08 mm(SD，0.07)。在呼吸分类的CBCT扫描上进行严格的肝对肝登记后，在腹部加压下接受SBRT的患者中，大部分患者的部分肝脏变形较小(<；5 mm)。
For patients receiving liver stereotactic body radiotherapy (SBRT), abdominal compression can reduce organ motion, and daily image guidance can reduce setup error. The reproducibility of liver shape under compression may impact treatment delivery accuracy. The purpose of this study was to measure the interfractional variability in liver shape under compression, after best-fit rigid liver-to-liver registration from kilovoltage (kV) cone beam computed tomography (CBCT) scans to planning computed tomography (CT) scans and its impact on gross tumor volume (GTV) position. Evaluable patients were treated in a Research Ethics Board–approved SBRT six-fraction study with abdominal compression. Kilovoltage CBCT scans were acquired before treatment and reconstructed as respiratory sorted CBCT scans offline. Manual rigid liver-to-liver registrations were performed from exhale-phase CBCT scans to exhale planning CT scans. Each CBCT liver was contoured, exported, and compared with the planning CT scan for spatial differences, by use of in house–developed finite-element model–based deformable registration (MORFEUS). We evaluated 83 CBCT scans from 16 patients with 30 GTVs. The mean volume of liver that deformed by greater than 3 mm was 21.7%. Excluding 1 outlier, the maximum volume that deformed by greater than 3 mm was 36.3% in a single patient. Over all patients, the absolute maximum deformations in the left–right (LR), anterior–posterior (AP), and superior–inferior directions were 10.5 mm (SD, 2.2), 12.9 mm (SD, 3.6), and 5.6 mm (SD, 2.7), respectively. The absolute mean predicted impact of liver volume displacements on GTV by use of center of mass displacements was 0.09 mm (SD, 0.13), 0.13 mm (SD, 0.18), and 0.08 mm (SD, 0.07) in the left–right, anterior–posterior, and superior–inferior directions, respectively. Interfraction liver deformations in patients undergoing SBRT under abdominal compression after rigid liver-to-liver registrations on respiratory sorted CBCT scans were small in most patients (<5 mm).
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DOI：
10.1016/j.ijrobp.2003.08.025
发表时间：
2003-12-01
影响因子：
7
作者：
Rosu, M;Dawson, LA;Haken, RKT
通讯作者：
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DOI：
10.1016/s0360-3016(01)01649-2
发表时间：
2001-09-01
影响因子：
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作者：
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DOI：
10.1016/s0360-3016(00)00610-6
发表时间：
2000-09-01
影响因子：
7
作者：
Aruga, T;Itami, J;Ito, H
通讯作者：
Ito, H
影响因子：
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DOI：
10.1016/j.ijrobp.2009.09.008
发表时间：
2010-07-01
影响因子：
7
作者：
Case, Robert B.;Moseley, Douglas J.;Dawson, Laura A.
通讯作者：
Dawson, Laura A.