Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
复制标题
维生素 D 状态影响女性青少年冬季血清甲状旁腺激素浓度：与前臂骨矿物质密度的关联。
DOI：
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复制
发表时间：
2001
影响因子：
7.1
通讯作者：
C. Lamberg‐Allardt
中科院分区：
文献类型：
--
作者：
T. Outila;M. Kärkkäinen;C. Lamberg‐Allardt
背景
BACKGROUND
Vitamin D deficiency leads to secondary hyperparathyroidism, which has a negative effect on bone metabolism in the elderly. Puberty is an important time of bone metabolism and growth. The effect of serum 25-hydroxyvitamin D [25(OH)D] concentrations on parathyroid hormone concentrations and bone mineral density (BMD) has not been well studied cross-sectionally in adolescents.
OBJECTIVE
We studied the effect of vitamin D status on serum intact parathyroid hormone (iPTH) concentrations and bone metabolism in adolescents.
DESIGN
One hundred seventy-eight healthy female adolescents (aged 14-16 y) volunteered for this study, which was conducted in Finland (Helsinki, 60 degrees N) during the winter. Forearm BMD at radial and ulnar sites was measured by dual energy X-ray absorptiometry. The determinants of different variables were studied by use of regression models.
RESULTS
On the basis of the relation between serum 25(OH)D and iPTH concentrations, serum 25(OH)D concentrations > approximately 40 nmol/L were needed to keep serum iPTH concentrations low. One hundred ten subjects (61.8%) had serum 25(OH)D concentrations < or =40 nmol/L. Twenty-four subjects (13.5%) were considered vitamin D deficient when the serum 25(OH)D concentration of 25 nmol/L was used as a cutoff. Subjects with serum 25(OH)D concentrations < or =40 nmol/L had low mean forearm BMD values at both the radial (P = 0.04) and ulnar (P = 0.08) sites.
CONCLUSION
A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
影响因子：
7.1
作者：
Jacques, PF;Felson, DT;Rush, D
通讯作者：
Rush, D
影响因子：
7.1
作者：
Kinyamu, HK;Gallagher, JC;Balhorn, KE
通讯作者：
Balhorn, KE
新英格兰北部的老年妇女的骨矿物质密度和促钙激素表现出季节性变化。
DOI：
10.1016/s0169-6009(08)80250-4
发表时间：
1994
期刊：
Bone and mineral
影响因子：
--
作者：
Rosen,CJ;Morrison,A;Zhou,H;Storm,D;Hunter,SJ;Musgrave,K;Chen,T;Wei,W;Holick,MF
通讯作者：
Holick,MF