T Cell Immunosenescence in Aging, Obesity, and Cardiovascular Disease.
T Cell Immunosenescence in Aging, Obesity, and Cardiovascular Disease.
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作者：
Shirakawa K;Sano M
虽然预防医学的进步大大改善了预后，但心血管疾病（CVD）仍然是全球死亡的主要原因。这清楚地表明，仍然存在传统疗法没有针对的残余心血管风险。多项动物研究和临床试验的结果清楚地表明，炎症是最重要的剩余风险，也是CVD预防的潜在目标。免疫细胞网络受到复杂的调节以维持体内平衡。与衰老相关的免疫系统变化发生在先天性和适应性免疫细胞中，然而T细胞最容易受到这一过程的影响。由于胸腺变性和稳态增殖、代谢异常、端粒长度缩短以及与衰老和肥胖相关的表观遗传变化引起的T细胞变化不仅可以降低正常的免疫功能，还可以诱导炎症倾向，这一过程称为免疫衰老。由于T细胞免疫衰老对生物稳态的破坏与炎症引起的CVD的发展和进展密切相关，衰老T细胞作为新的治疗靶点引起了人们的关注。在这篇综述中，我们讨论了CVD和T细胞免疫衰老与衰老和肥胖之间的关系。
Although advances in preventive medicine have greatly improved prognosis, cardiovascular disease (CVD) remains the leading cause of death worldwide. This clearly indicates that there remain residual cardiovascular risks that have not been targeted by conventional therapies. The results of multiple animal studies and clinical trials clearly indicate that inflammation is the most important residual risk and a potential target for CVD prevention. The immune cell network is intricately regulated to maintain homeostasis. Ageing associated changes to the immune system occurs in both innate and adaptive immune cells, however T cells are most susceptible to this process. T-cell changes due to thymic degeneration and homeostatic proliferation, metabolic abnormalities, telomere length shortening, and epigenetic changes associated with aging and obesity may not only reduce normal immune function, but also induce inflammatory tendencies, a process referred to as immunosenescence. Since the disruption of biological homeostasis by T cell immunosenescence is closely related to the development and progression of CVD via inflammation, senescent T cells are attracting attention as a new therapeutic target. In this review, we discuss the relationship between CVD and T cell immunosenescence associated with aging and obesity.
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影响因子：
32.4
作者：
Goronzy JJ;Weyand CM
通讯作者：
Weyand CM
终末分化的 CD4(+) T 细胞会促进心肌炎症。
影响因子：
7.3
作者：
Delgobo M;Heinrichs M;Hapke N;Ashour D;Appel M;Srivastava M;Heckel T;Spyridopoulos I;Hofmann U;Frantz S;Ramos GC
通讯作者：
Ramos GC
DOI：
10.1038/nri2888
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1038/s41577-019-0180-1
发表时间：
2019-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Goronzy JJ;Weyand CM
通讯作者：
Weyand CM
影响因子：
82.9
作者：
Frodermann, Vanessa;Rohde, David;Nahrendorf, Matthias
通讯作者：
Nahrendorf, Matthias