Smoking and drinking in relation to depressive symptoms among persons with oral cancer or oral epithelial dysplasia.

Smoking and drinking in relation to depressive symptoms among persons with oral cancer or oral epithelial dysplasia.
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DOI:
10.1002/hed.21227
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发表时间:
2010-05
影响因子:
2.9
通讯作者:
Reisine, Susan
Reisine, Susan
中科院分区:
医学2区
文献类型:
--
作者:
Morse, Douglas E.;Psoter, Walter J.;Baek, Linda S.;Eisenberg, Ellen;Cohen, Donald;Cleveland, Deborah;Mohit-Tabatabai, Mirseyed;Reisine, Susan

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我们研究了在口腔癌或口腔上皮异型增生(OED)诊断年期间或之前吸烟或饮酒是否与口腔诊断数月后测量的“后续抑郁”有关。口腔癌或OED的病例通过3个口腔病理实验室进行鉴定。电话问卷包括诊断年度的吸烟史/饮酒史问题,并使用流行病学研究中心抑郁量表(CES-D)测量抑郁症状;得分16+表示临床抑郁。“后续抑郁”被定义为16+的CES-D评分,在口腔癌或OED诊断后几个月进行评估时测量。与既往吸烟者/从不吸烟者相比,在诊断年吸烟的患者随后患抑郁症的几率是前者的两倍。诊断年份(与从未/既往)饮酒与抑郁无关;然而,平均每周饮酒1.5杯与诊断年份和既往饮酒者(过去报告饮酒)的随后抑郁呈负相关,即使在酗酒者中也是如此。我们的研究结果表明,在确诊年份和戒酒者中,随后的抑郁与确诊年吸烟呈正相关,与每周饮酒1.5英镑的饮酒量呈负相关。
We examined whether smoking or drinking during or before the diagnosis-year of oral cancer or oral epithelial dysplasia (OED) was related to “subsequent depression” measured months after the oral diagnosis. Incident cases of oral cancer or OED were identified via 3 oral pathology laboratories. A telephone-administered questionnaire included questions on smoking/drinking history through the diagnosis-year and measured depressive symptoms using the Center for Epidemiologic Studies-Depression Scale (CES-D); scores of 16+ indicated clinical depression. “Subsequent depression” was defined as a CES-D score of 16+, measured at the time of assessment several months after the diagnosis of oral cancer or OED. Patients who smoked during their diagnosis-year had twice the odds of subsequent depression relative to former/never smokers. Diagnosis-year (vs never/former) drinking was not associated with depression; however, average alcohol consumption of >1.5 drinks/week was negatively associated with subsequent depression for both diagnosis-year and ex-drinkers (past reported drinking) even among heavy drinkers. Our findings suggest that subsequent depression is positively associated with diagnosis-year smoking and negatively associated with alcohol consumption of >1.5 drinks/week among both diagnosis-year and ex-drinkers.
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