Neutrophil-mediated mucosal injury
Neutrophil-mediated mucosal injury
复制标题
中性粒细胞介导的粘膜损伤
DOI：
--
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发表时间：
1988
影响因子：
3.1
通讯作者：
D. Granger
中科院分区：
文献类型：
--
作者：
M. Grisham;D. Granger
活性氧代谢物 (ROM) 是部分还原的氧物质，包括超氧化物、过氧化氢、羟基自由基和次卤酸。形成超氧化物或过氧化氢可能直接损害组织；然而，人们认为组织损伤的主要介质是次生氧化剂，例如羟自由基和次卤酸。胃肠道特别具有形成大量ROM所需的酶机制。胃肠道中ROM的来源包括粘膜氧化酶，例如黄嘌呤氧化酶、胺氧化酶和醛氧化酶，以及固有层吞噬性白细胞（巨噬细胞、中性粒细胞、嗜酸性粒细胞）中发现的NADPH氧化酶。我们已经证明，缺血性小肠的再灌注会导致由黄嘌呤氧化酶和炎症白细胞产生的氧自由基介导的严重粘膜损伤。最终的毒性介质似乎是由铁催化的超氧化物和过氧化氢之间的相互作用产生的羟基自由基。来自我们实验室以及其他实验室的数据表明，活性氧代谢物可能在溃疡性结肠炎活动发作期间介导粘膜损伤中发挥重要作用。我们提出了一个可行的假设，该假设指出肠道中的短暂性缺血发作会引发 ROM 形成、炎症以及最终粘膜损伤的一系列自我延续循环。
Reactive oxygen metabolites (ROMs) are partially reduced oxygen species that include Superoxide, hydrogen peroxide, hydroxyl radical, and hypohalous acids. Formation of Superoxide or hydrogen peroxide may be injurious to tissue directly; however, it is thought that the primary mediators of tissue damage are the secondarily derived oxidants such as hydroxyl radical and hypohalous acid. The gastrointestinal tract is particularly well endowed with the enzymatic machinery necessary to form large amounts of ROMs. Sources of ROMs in the gastrointestinal tract include mucosal oxidases such as xanthine oxidase, amine oxidase, and aldehyde oxidase as well as the NADPH oxidase found in the resident phagocytic leukocytes (macrophages, neutrophils, eosinophils) of the lamina propria. We have demonstrated that reperfusion of ischemic small intestine results in substantial mucosal injury that is mediated by oxy radicals generated from xanthine oxidase and inflammatory leukocytes. The final mediator of toxicity appears to be the hydroxyl radical derived from the iron-catalyzed interaction between Superoxide and hydrogen peroxide. Data from our laboratories as well as other laboratories suggest that reactive oxygen metabolites may play an important role in mediating mucosal injury during active episodes of ulcerative colitis. We present a working hypothesis which states that transient ischemic episodes in the bowel initiate a cascade of self-perpetuating cycles of ROM formation, inflammation and, ultimately, mucosal injury.
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影响因子：
56.9
作者：
AMES, BN
通讯作者：
AMES, BN
影响因子：
--
作者：
GRISHAM, MB;HERNANDEZ, LA;GRANGER, DN
通讯作者：
GRANGER, DN
牛磺酸在中性粒细胞对红细胞的体外氧化毒性中作用的证据。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Thomas,EL;Grisham,MB;Melton,DF;Jefferson,MM
通讯作者：
Jefferson,MM
DOI：
10.1016/s0021-9258(19)70209-9
发表时间：
1980-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
R. Burger;Allen R. Berkowitz;J. Peisach;Susan Band
通讯作者：
R. Burger;Allen R. Berkowitz;J. Peisach;Susan Band
白细胞和缺血引起的心肌损伤。
DOI：
10.1146/annurev.pa.26.040186.001221
发表时间：
1986
影响因子：
12.5
作者：
Lucchesi,BR;Mullane,KM
通讯作者：
Mullane,KM