Oral cancer patients experience mechanical and chemical sensitivity at the site of the cancer.
Oral cancer patients experience mechanical and chemical sensitivity at the site of the cancer.
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DOI：
10.1186/s12885-022-10282-3
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发表时间：
2022-11-11
期刊：
影响因子：
3.8
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中科院分区：
文献类型：
--
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口腔癌患者在癌症病灶部位遭受严重的慢性疼痛以及机械性诱发的疼痛。我们的临床经验表明，口腔癌患者自述对辛辣食物出现新的敏感情况。我们假设，与对侧匹配的正常部位相比，在癌症患者中，测量癌症病灶部位时，其机械和化学敏感性会更高。
我们测定了11名健康受试者舌头左右两侧的机械痛阈（MPT），以及11名口腔癌患者癌症病灶部位和对侧匹配正常部位对0.008至300克范围（通常不会引起疼痛）的冯·弗雷细丝刺激的反应。我们评估了13名健康受试者和7名癌症患者的化学敏感性，这些受试者在接触六条浸有辣椒素（0 - 10毫摩尔）的纸条后，通过视觉模拟量表对辛辣感/疼痛感进行评分。
记录了健康受试者的机械察觉阈（MDT），但未记录MPT。相比之下，在11名口腔癌患者中有7名测量到了癌症病灶部位的MPT。在癌症患者对侧匹配的正常部位未测量到MPT。测量得到的MPT与患者对加州大学口腔癌疼痛问卷的回答相关。与患者对侧匹配的正常部位相比，癌症患者癌症病灶部位的辣椒素剂量 - 反应曲线左移，表明癌症患者癌症病灶部位对辣椒素敏感。我们未检测到健康受试者舌头左右两侧对辣椒素敏感性的差异。
大多数口腔癌患者对机械和化学敏感性测试耐受良好。癌症病灶部位的敏感性高于对侧匹配的正常部位。
在线版本包含补充材料，网址为10.1186/s12885 - 022 - 10282 - 3。
Oral cancer patients suffer severe chronic and mechanically-induced pain at the site of the cancer. Our clinical experience is that oral cancer patients report new sensitivity to spicy foods. We hypothesized that in cancer patients, mechanical and chemical sensitivity would be greater when measured at the cancer site compared to a contralateral matched normal site. We determined mechanical pain thresholds (MPT) on the right and left sides of the tongue of 11 healthy subjects, and at the cancer and contralateral matched normal site in 11 oral cancer patients in response to von Frey filaments in the range of 0.008 to 300 g (normally not reported as painful). We evaluated chemical sensitivity in 13 healthy subjects and seven cancer patients, who rated spiciness/pain on a visual analog scale in response to exposure to six paper strips impregnated with capsaicin (0–10 mM). Mechanical detection thresholds (MDT) were recorded for healthy subjects, but not MPTs. By contrast, MPTs were measured at the site of the cancer in oral cancer patients (7/11 patients). No MPTs were measured at the cancer patients’ contralateral matched normal sites. Measured MPTs were correlated with patients’ responses to the University of California Oral Cancer Pain Questionnaire. Capsaicin sensitivity at the site of the cancer was evident in cancer patients by a leftward shift of the cancer site capsaicin dose-response curve compared to that of the patient’s contralateral matched normal site. We detected no difference in capsaicin sensitivity on the right and left sides of tongues of healthy subjects. Mechanical and chemical sensitivity testing was well tolerated by the majority of oral cancer patients. Sensitivity is greater at the site of the cancer than at a contralateral matched normal site. The online version contains supplementary material available at 10.1186/s12885-022-10282-3.
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