Social smiling and its components in high-risk infant siblings without later ASD symptomatology.
Social smiling and its components in high-risk infant siblings without later ASD symptomatology.
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DOI：
10.1007/s10803-013-1944-2
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
Stone WL
中科院分区：
文献类型：
--
作者：
Nichols CM;Ibañez LV;Foss-Feig JH;Stone WL
情感表达受损，包括社交微笑，在自闭症谱系障碍(ASD)儿童中很常见，可能是他们婴儿兄弟姐妹(Sibs-ASD)ASD的早期标志。15个月后，在表现出ASD症状的SIBS-ASD组(SIBS-ASD/AS)、没有表现出ASD症状的SIBS-ASD/NS组和低危对照组(SIBS-TD)中，对社交微笑及其组成部分行为(眼神接触和非社交微笑)进行了检查。两个SIBS-ASD亚组都表现出比SIBS-TD更低的社交微笑水平，这表明早期社交微笑可能反映了遗传易感性的增加，而不是ASD的一个特定标记。只有SIBS-ASD/AS比SIBS-TD表现出更少的眼神接触和非社交微笑，这表明不同的过程、阈值效应或保护因素可能是两个SIBS-ASD亚组社交微笑发展的基础。
Impaired affective expression, including social smiling, is common in children with autism spectrum disorder (ASD), and may represent an early marker for ASD in their infant siblings (Sibs-ASD). Social smiling and its component behaviors (eye contact and non-social smiling) were examined at 15 months in Sibs-ASD who demonstrated later ASD symptomatology (Sibs-ASD/AS), those who did not (Sibs-ASD/NS), and low-risk controls (Sibs-TD). Both Sibs-ASD subgroups demonstrated lower levels of social smiling than Sibs-TD, suggesting that early social smiling may reflect elevated genetic vulnerability rather than a specific marker for ASD. Only the Sibs-ASD/AS demonstrated less eye contact and non-social smiling than Sibs-TD, suggesting that different processes, threshold effects, or protective factors may underlie social smiling development in the two Sibs-ASD subgroups.
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