Controlled drug delivery systems: past forward and future back.
Controlled drug delivery systems: past forward and future back.
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DOI：
10.1016/j.jconrel.2014.03.054
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发表时间：
2014-09-28
期刊：
影响因子：
--
通讯作者：
Park K
中科院分区：
文献类型：
--
作者：
Park K
受控药物输送技术在过去六年中取得了进步。它始于 1952 年，推出了第一个缓释制剂。第一代（1950-1980）药物递送技术的重点是开发口服和透皮缓释系统并建立药物控释机制。第二代（1980-2010）的注意力致力于零级释放系统、自调节药物递送系统、长期储库制剂和基于纳米技术的递送系统的开发。第二代的后半部分主要用于研究纳米颗粒配方。 《控释杂志》(JCR) 在第二代药物输送技术中发挥了关键作用，并将继续在下一代药物输送技术中发挥主导作用。走向高效的第三代药物输送技术的正确道路需要诚实的公开对话，而不是任何过去的先入为主的想法。药物输送领域需要首先根据当今的需求采取大胆的方法设计未来的药物输送配方，并进行必要的创新。 JCR 将为分享塑造第三代药物输送技术的新想法提供论坛。
The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms. Attention of the 2nd generation (1980-2010) was dedicated to development of zero-order release systems, self-regulated drug delivery systems, long-term depot formulations, and nanotechnology-based delivery systems. The latter part of the 2nd generation was consumed mostly for studying nanoparticle formulations. The Journal of Controlled Release (JCR) has played a pivotal role during the 2nd generation of drug delivery technologies, and it will continue playing a leading role for the next generation. Taking the right path towards the productive 3rd generation of drug delivery technologies requires honest open dialogues without any preconceived ideas of the past. The drug delivery field needs to take a bold approach of designing the future drug delivery formulations first, based on today’s necessities, and produce necessary innovations. The JCR will provide the forum for sharing the new ideas that will shape the 3rd generation of drug delivery technologies.
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影响因子：
10.8
作者：
BRANNONPEPPAS, L;PEPPAS, NA
通讯作者：
PEPPAS, NA
影响因子：
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作者：
DONG, LC;HOFFMAN, AS
通讯作者：
HOFFMAN, AS
DOI：
10.1016/j.jconrel.2013.06.039
发表时间：
2013-11-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
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通讯作者：
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影响因子：
10.8
作者：
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通讯作者：
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影响因子：
10.8
作者：
Cheng, Ru;Feng, Fang;Zhong, Zhiyuan
通讯作者：
Zhong, Zhiyuan