Soluble Receptors Affecting Stroke Outcomes: Potential Biomarkers and Therapeutic Tools.
Soluble Receptors Affecting Stroke Outcomes: Potential Biomarkers and Therapeutic Tools.
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DOI：
10.3390/ijms22031108
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发表时间：
2021-01-23
影响因子：
5.6
通讯作者：
Doré S
中科院分区：
文献类型：
--
作者：
Bhattacharya A;Ashouri R;Fangman M;Mazur A;Garett T;Doré S
可溶性受体被广泛理解为通过从其膜结合的对应物裂解而形成的独立部分。它们具有独特的结构，存在于各种受体家族中，并且具有有趣的生成和释放机制。可溶性受体通过受体调节或通过在细胞保护和神经炎症中表现出双重作用而表现出多效性作用的能力是浓度依赖性的，并且一直使研究人员感到困惑。在这里，我们收集了来自临床前和临床研究的发现，以深入了解可溶性/诱饵受体的作用，重点是可溶性分化簇36，可溶性分化簇163和可溶性脂蛋白相关蛋白1（分别为sCD 36、sCD 163和sLRP 1）以及它们可能在卒中管理中发挥的功能，因为它们将显著地调节红细胞溶解后血红蛋白和血红素的生物利用度。这些可溶性受体在炎症、氧化应激和改善卒中结局的相关药理学潜力中发挥的关键作用被描述。可溶性受体的确切多效性生理功能尚不清楚，需要进一步的科学研究/验证以确定其各自在诊断和治疗中的作用。
Soluble receptors are widely understood to be freestanding moieties formed via cleavage from their membrane-bound counterparts. They have unique structures, are found among various receptor families, and have intriguing mechanisms of generation and release. Soluble receptors’ ability to exhibit pleiotropic action by receptor modulation or by exhibiting a dual role in cytoprotection and neuroinflammation is concentration dependent and has continually mystified researchers. Here, we have compiled findings from preclinical and clinical studies to provide insights into the role of soluble/decoy receptors, focusing on the soluble cluster of differentiation 36, the soluble cluster of differentiation 163, and soluble lipoprotein-related protein 1 (sCD36, sCD163, and sLRP1, respectively) and the functions they could likely serve in the management of stroke, as they would notably regulate the bioavailability of the hemoglobin and heme after red blood cell lysis. The key roles that these soluble receptors play in inflammation, oxidative stress, and the related pharmacotherapeutic potential in improving stroke outcomes are described. The precise pleiotropic physiological functions of soluble receptors remain unclear, and further scientific investigation/validation is required to establish their respective role in diagnosis and therapy.
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