Soluble CD163 as a Potential Biomarker in Systemic Sclerosis.
Soluble CD163 as a Potential Biomarker in Systemic Sclerosis.
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DOI：
10.1155/2018/8509583
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Allanore Y
中科院分区：
文献类型：
--
作者：
Frantz C;Pezet S;Avouac J;Allanore Y
评估血清和尿液sCD163浓度作为系统性硬化症（SSc）可能的生物标志物的性能。从SSc患者和年龄和性别匹配的对照组中获得尿液和血清样本。采用市售ELISA试剂盒检测血清和尿液sCD163浓度。SSc患者按照国际指南进行评估。进行横断面分析。纳入了203例SSc患者。对照组包括47例年龄和性别匹配的非炎症性疾病，主要是骨质疏松症。SSc患者血清sCD163水平显著高于对照组（平均±SD: 529±251比385±153 ng/mL； p < 0.001）。SSc患者尿sCD163浓度高于对照组，但差异无统计学意义（236±498对176±173 ng/mg uCr； p = 0.580）。sCD163浓度与SSc患者的临床、实验室和仪器特征无关。据我们所知，这是首次对SSc患者血清和尿液sCD163水平进行评估。我们的结果显示，与尿液测量相比，血清值应优先进行进一步研究的显著差异。我们的研究结果进一步支持M2巨噬细胞/CD163信号系统可能在SSc的发病机制中发挥作用，尽管我们无法确定更高浓度的SSc患者亚群。
To evaluate the performance of serum and urinary sCD163 concentrations as possible biomarker in systemic sclerosis (SSc). Urine and serum samples were obtained from SSc patients and age- and sex-matched controls. Serum and urinary sCD163 concentrations were measured by commercially available ELISA kit. SSc patients were assessed following international guidelines. Cross-sectional analyses were performed. Two hundred and three SSc patients were included. The control group consisted of 47 age- and sex-matched patients having noninflammatory diseases, mainly osteoporosis. Serum sCD163 levels were significantly higher in SSc patients compared with controls (mean ± SD: 529 ± 251 versus 385 ± 153 ng/mL; p < 0.001). Urinary sCD163 concentrations were higher in SSc patients than controls, but this did not reach significance (236 ± 498 versus 176 ± 173 ng/mg uCr; p = 0.580). The sCD163 concentrations were not associated with clinical, laboratory, and instrumental characteristics of SSc patients. To our knowledge, this is the first evaluation of both serum and urinary sCD163 levels in SSc. Our results show a significant difference for sera values that should be prioritized for further studies as compared to urinary measurements. Our results further support that the M2 macrophages/CD163 signaling system may play a role in the pathogenesis of SSc, although we could not identify a subset of SSc patients with higher concentrations.
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影响因子：
2
作者：
Khanna D;Furst DE;Clements PJ;Allanore Y;Baron M;Czirjak L;Distler O;Foeldvari I;Kuwana M;Matucci-Cerinic M;Mayes M;Medsger T Jr;Merkel PA;Pope JE;Seibold JR;Steen V;Stevens W;Denton CP
通讯作者：
Denton CP
影响因子：
32.4
作者：
Wynn TA;Vannella KM
通讯作者：
Vannella KM
影响因子：
--
作者：
van den Hoogen, Frank;Khanna, Dinesh;Fransen, Jaap;Johnson, Sindhu R.;Baron, Murray;Tyndall, Alan;Matucci-Cerinic, Marco;Naden, Raymond P.;Medsger, Thomas A., Jr.;Carreira, Patricia E.;Riemekasten, Gabriela;Clements, Philip J.;Denton, Christopher P.;Distler, Oliver;Allanore, Yannick;Furst, Daniel E.;Gabrielli, Armando;Mayes, Maureen D.;van Laar, Jacob M.;Seibold, James R.;Czirjak, Laszlo;Steen, Virginia D.;Inanc, Murat;Kowal-Bielecka, Otylia;Mueller-Ladner, Ulf;Valentini, Gabriele;Veale, Douglas J.;Vonk, Madelon C.;Walker, Ulrich A.;Chung, Lorinda;Collier, David H.;Csuka, Mary Ellen;Fessler, Barri J.;Guiducci, Serena;Herrick, Ariane;Hsu, Vivien M.;Jimenez, Sergio;Kahaleh, Bashar;Merkel, Peter A.;Sierakowski, Stanislav;Silver, Richard M.;Simms, Robert W.;Varga, John;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
4.4
作者：
Martinez, Fernando O.;Gordon, Siamon;Mantovani, Alberto
通讯作者：
Mantovani, Alberto
影响因子：
4
作者：
Nakayama, Wakana;Jinnin, Masatoshi;Ihn, Hironobu
通讯作者：
Ihn, Hironobu