Histamine in the regulation of wakefulness.
Histamine in the regulation of wakefulness.
复制标题
组胺在调节中。
DOI：
10.1016/j.smrv.2010.06.004
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发表时间：
2011-02
影响因子：
10.5
通讯作者：
Thakkar MM
中科院分区：
文献类型：
--
作者：
Thakkar MM
The histaminergic system is exclusively localized within the posterior hypothalamus with projection to almost all the major regions of the central nervous system. Strong and consistent evidence exist to suggest that histamine, acting via H1 and/or H3 receptor has a pivotal role in the regulation of sleep-wakefulness. Administration of histamine or H1 receptor agonists induced wakefulness, whereas administration of H1 receptor antagonists promoted sleep. The H3 receptor functions as an auto-receptor and regulates the synthesis and release of histamine. Activation of H3 receptor decreased histamine release and promoted sleep. Conversely, blockade of H3 receptor promoted wakefulness. Histamine release in the hypothalamus and other target regions was highest during wakefulness. The histaminergic neurons displayed maximal activity during the state of vigilance, and cease their activity during NREM and REM sleep. The cerebrospinal levels of histamine were reduced in diseased states where hypersomnolence was a major symptom. The histamine deficient HDC KO mice displayed sleep fragmentation and increased REM sleep during the light period along with profound wakefulness deficit at dark onset, and in novel environment. Similar results were obtained when histamine neurons were lesioned. These studies strongly implicate the histaminergic neurons of the TMN to play a critical role in the maintenance of high vigilance state during wakefulness.
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影响因子：
64.8
作者：
Gallopin, T;Fort, P;Serafin, M
通讯作者：
Serafin, M
影响因子：
2.5
作者：
ERICSON, H;WATANABE, T;KOHLER, C
通讯作者：
KOHLER, C
影响因子：
64.5
作者：
Chemelli, RM;Willie, JT;Yanagisawa, M
通讯作者：
Yanagisawa, M
组胺 H1 受体敲除小鼠的睡眠-觉醒特征发生改变，且对 H3 受体拮抗剂缺乏唤醒反应。
DOI：
10.1073/pnas.0600451103
发表时间：
2006-03-21
影响因子：
11.1
作者：
Huang, ZL;Mochizuki, T;Hayaishi, O
通讯作者：
Hayaishi, O
影响因子：
7.3
作者：
Barbier, AJ;Berridge, C;Lovenberg, TW
通讯作者：
Lovenberg, TW