Characteristics of late negative ERG responses elicited by sawtooth flicker.
Characteristics of late negative ERG responses elicited by sawtooth flicker.
复制标题
锯齿闪烁引起的晚期ERG反应的特征。
DOI：
10.1007/s10633-012-9352-z
复制
发表时间：
2013-02
影响因子：
1.4
通讯作者：
Alexander, Kenneth R.
中科院分区：
文献类型：
--
作者：
Gowrisankaran, Sowjanya;Genead, Mohamed A.;Anastasakis, Anastasios;Alexander, Kenneth R.
本研究的目的是确定是否晚负反应（LNR）的性质引起的视网膜电图（ERG）的闪烁是一致的，由光脉冲（PhNR脉冲）产生的明视负反应的特性。对10名视力正常的人和6名视神经萎缩（OA）患者进行了ERG记录，记录了对8-Hz快速开启和快速关闭闪烁和短暂（4 ms）光脉冲的反应。所有的刺激要么是长波长（R），中波长（G），或长波长和中波长（Y）的相等亮度的组合呈现在一个短波长，杆饱和适应场。LNR的振幅响应于快速开启（LNRon）和快速关闭（LNRoff）闪烁而获得，并且也来自两个闪烁相的ERG波形的总和（LNRadd）。对于对照受试者，PhNR脉冲幅度随刺激波长而变化，如预期的那样，在响应长波长脉冲时最大。然而，对于R、Y和G闪烁，LNRon、LNRoff和LNRadd的幅度没有显著差异。尽管没有色效应，但OA患者的LNRoff和LNRadd振幅明显小于对照组，与PhNR脉冲的结果相似，这意味着LNRoff和LNRadd的视网膜起源。然而，LNRon幅度没有显着差异OA患者和对照组之间，虽然有一个显着的相关性LNRon和PhNR脉冲R刺激。我们的结论是，LNRoff和LNRadd，但不是LNRon可以是有用的措施，以评估完整的内层视网膜，可以补充PhNR脉冲。
This study aimed to determine whether the properties of the late negative responses (LNRs) of the electroretinogram (ERG) elicited by sawtooth flicker are consistent with the characteristics of the photopic negative response generated by a light pulse (PhNRpulse). ERG recordings were obtained from 10 visually normal individuals and from 6 patients with optic atrophy (OA) in response to 8-Hz rapid-on and rapid-off sawtooth flicker and to brief (4 ms) light pulses. All stimuli were either long-wavelength (R), middle-wavelength (G), or a combination of equal luminances of long and middle-wavelengths (Y) presented on a short-wavelength, rod-saturating adapting field. Amplitudes of LNRs were obtained in response to rapid-on (LNRon) and rapid-off (LNRoff) sawtooth flicker, and were also derived from the sum of the ERG waveforms to the two sawtooth phases (LNRadd). For the control subjects, PhNRpulse amplitude varied with stimulus wavelength, being largest in response to a long-wavelength pulse, as expected. However, the amplitudes of LNRon, LNRoff, and LNRadd were not significantly different for R, Y, and G sawtooth flicker. Despite the absence of a chromatic effect, LNRoff and LNRadd amplitudes were significantly smaller in the OA patients than in the controls, similar to the results for the PhNRpulse, implying an inner retinal origin for the LNRoff and LNRadd. However, LNRon amplitudes did not differ significantly between the OA patients and controls, although there was a significant correlation between the LNRon and PhNRpulse for R stimuli. We conclude that LNRoff and LNRadd but not LNRon can be useful measures to assess the integrity of the inner retina that can complement the PhNRpulse.
登录
查看更多内容
影响因子：
1.4
作者：
Sustar, Maja;Cvenkel, Barbara;Brecelj, Jelka
通讯作者：
Brecelj, Jelka
影响因子：
4.4
作者：
Miyata, Kentaro;Nakamura, Makoto;Terasaki, Hiroko
通讯作者：
Terasaki, Hiroko
影响因子：
1.4
作者：
Pangeni, Gobinda;Laemmer, Robert;Kremers, Jan
通讯作者：
Kremers, Jan
影响因子：
1.4
作者：
Horn, Folkert K.;Gottschalk, Kristina;Kremers, Jan
通讯作者：
Kremers, Jan
影响因子：
4.4
作者：
Luo, Xunda;Frishman, Laura J.
通讯作者：
Frishman, Laura J.