The convergence theory for vitiligo: A reappraisal.
The convergence theory for vitiligo: A reappraisal.
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DOI：
10.1111/exd.13677
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发表时间：
2019-06
影响因子：
3.6
通讯作者：
Le Poole IC
中科院分区：
文献类型：
--
作者：
Kundu RV;Mhlaba JM;Rangel SM;Le Poole IC
白癜风的特征是皮肤色素逐渐缺失。对病因的探索产生了生化理论、神经理论和自身免疫理论。几年前又提出了融合理论，将现有的白癜风发病理论整合到一个关于白癜风病因的综述中。白癜风并非仅仅由易感突变引起，也不是仅仅由黑素细胞对化学物质/辐射暴露作出反应引起，或者仅仅由高反应性T细胞引起，而是由影响黑素细胞生存能力的多种病因因素共同作用的结果，这一观点无疑经受住了时间的考验。此后的新发现为对色素逐渐脱失的描述提供了依据。了解这些病因因素的相对重要性，并精心选择最具靶向性的途径，将继续推动白癜风研究进入下一阶段：开发有效的治疗方法。在这方面，同样重要的是要认识到，一些患者中受影响的途径在其他患者中可能没有改变。综上所述，融合理论继续为白癜风病因提供了一个全面的观点。该理论将病因途径相互交织，有助于确定适合个体患者疾病干预的途径。
Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo aetiology. The viewpoint that vitiligo is not caused only by predisposing mutations, or only by melanocytes responding to chemical/radiation exposure, or only by hyperreactive T cells, but rather results from a combination of aetiologic factors that impact melanocyte viability, has certainly stood the test of time. New findings have since informed the description of progressive depigmentation. Understanding the relative importance of such aetiologic factors combined with a careful selection of the most targetable pathways will continue to drive the next phase in vitiligo research: the development of effective therapeutics. In that arena, it is likewise important to acknowledge that pathways affected in some patients may not be altered in others. Taken together, the convergence theory continues to provide a comprehensive viewpoint of vitiligo aetiology. The theory serves to intertwine aetiologic pathways and will help to define pathways amenable to disease intervention in individual patients.
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影响因子：
64.5
作者：
Adameyko, Igor;Lallemend, Francois;Ernfors, Patrik
通讯作者：
Ernfors, Patrik
DOI：
10.1034/j.1600-0749.2003.00032.x
发表时间：
2003-06-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
Alkhateeb, A;Fain, PR;Spritz, RA
通讯作者：
Spritz, RA
DOI：
10.1097/pai.0b013e318246c793
发表时间：
2012-10-01
影响因子：
1.6
作者：
Abdou, Asmaa Gaber;Maraee, Alaa Hassan;Elbana, Rania
通讯作者：
Elbana, Rania
影响因子：
3.7
作者：
Bellei B;Pitisci A;Ottaviani M;Ludovici M;Cota C;Luzi F;Dell'Anna ML;Picardo M
通讯作者：
Picardo M
影响因子：
64.8
作者：
Basch, ML;Bronner-Fraser, M;García-Castro, MI
通讯作者：
García-Castro, MI