Harvesting the promise of AOPs: An assessment and recommendations.
Harvesting the promise of AOPs: An assessment and recommendations.
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DOI：
10.1016/j.scitotenv.2018.02.015
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发表时间：
2018-07-01
期刊：
影响因子：
--
通讯作者：
Ankley GT
中科院分区：
文献类型：
--
作者：
Carusi A;Davies MR;De Grandis G;Escher BI;Hodges G;Leung KMY;Whelan M;Willett C;Ankley GT
AOP框架旨在提高化学品安全评估的效率。然而，aop的利益相关者群体比化学品风险评估人员更广泛。要成功地让所有利益相关者参与进来，存在着科学和社会方面的挑战。多方面的沟通和治理战略将应对这些挑战。不利结果途径（AOP）概念是一种知识集合和交流工具，有助于将机制信息透明地转化为对化学品监管评估有意义的结果。AOP框架和相关的知识库（KBs）在监管毒理学界得到了极大的关注和使用。然而，越来越明显的是，AOP概念和AOP KBs的潜在利益相关者社区比直接参与化学安全评估的科学家和监管机构更广泛。在本文中，我们确定并描述了那些目前——或者将来——能够从AOP框架和知识的应用中受益的涉众。我们还总结了在生物科学中实施基于途径的方法（如AOP框架）所面临的挑战，并提供了一系列建议，以满足关键需求，以确保该框架进一步发展为支持人类健康和环境评估的有用、可持续和可靠的工具。尽管AOP概念有可能在各种学科/应用中对生物信息的组织和解释产生重大影响，但是这一承诺只能通过多个利益相关者的积极参与和投入来充分实现，这需要多管共进的实质性长期规划和战略。
The AOP framework aims to increase efficiency of chemical safety assessments. The stakeholder community for AOPs, however, is broader than chemical risk assessors. There are scientific and social challenges to successfully engage all stakeholders. Multi-faceted communication and governance strategies will address these challenges. The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies.
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