Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior.
Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior.
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DOI：
10.1038/s41467-018-03988-1
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发表时间：
2018-04-18
影响因子：
16.6
通讯作者：
Ma M
中科院分区：
文献类型：
--
作者：
Moberly AH;Schreck M;Bhattarai JP;Zweifel LS;Luo W;Ma M
已知通过鼻腔的呼吸和气流与中枢神经系统中的节律性神经活动相关。在这里，我们在啮齿动物中发现，在条件性恐惧诱导的冻结行为期间，小鼠以稳定的速率（约4 Hz）呼吸，这与前边缘前额叶皮层（plPFC）中占主导地位的4 Hz振荡相关，这是一种对条件性恐惧行为表达至关重要的结构。我们通过电路追踪和光遗传学证明了嗅觉通路和plPFC之间的解剖和功能联系。嗅觉输入的中断显着降低了4-Hz的振荡在plPFC，但导致延长冻结期。我们的研究结果表明，嗅觉输入可以调节节律性活动的前额叶皮层和冻结行为。鼻腔气流和嗅球活动与皮层区域的振荡有关。本研究表明，嗅觉输入和呼吸与小鼠冻结行为中前额叶皮层的振荡相关，嗅觉输入的减弱可以增加行为冻结。
Respiration and airflow through the nasal cavity are known to be correlated with rhythmic neural activity in the central nervous system. Here we show in rodents that during conditioned fear-induced freezing behavior, mice breathe at a steady rate (~4 Hz), which is correlated with a predominant 4-Hz oscillation in the prelimbic prefrontal cortex (plPFC), a structure critical for expression of conditioned fear behaviors. We demonstrate anatomical and functional connections between the olfactory pathway and plPFC via circuit tracing and optogenetics. Disruption of olfactory inputs significantly reduces the 4-Hz oscillation in the plPFC, but leads to prolonged freezing periods. Our results indicate that olfactory inputs can modulate rhythmic activity in plPFC and freezing behavior. Nasal airflow and olfactory bulb activity are linked to oscillations in cortical areas. This study shows olfactory input and respiration are correlated with oscillation in the prefrontal cortex during freezing behavior in mice, and attenuation of olfactory inputs can increase behavioral freezing.
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影响因子：
16.6
作者：
Ito, J.;Roy, S.;Liu, Y.;Cao, Y.;Fletcher, M.;Lu, L.;Boughter, J. D.;Gruen, S.;Heck, D. H.
通讯作者：
Heck, D. H.
DOI：
10.1523/jneurosci.0154-12.2012
发表时间：
2012-06-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Igarashi KM;Ieki N;An M;Yamaguchi Y;Nagayama S;Kobayakawa K;Kobayakawa R;Tanifuji M;Sakano H;Chen WR;Mori K
通讯作者：
Mori K
影响因子：
3.5
作者：
Buonviso, N;Amat, C;Litaudon, P
通讯作者：
Litaudon, P
DOI：
10.1073/pnas.0603081103
发表时间：
2006-06-06
影响因子：
11.1
作者：
Hnasko, Thomas S.;Perez, Francisco A.;Palmiter, Richard D.
通讯作者：
Palmiter, Richard D.
DOI：
10.1111/j.1749-6632.2009.04394.x
发表时间：
2009-01-01
期刊：
LONGEVITY, REGENERATION, AND OPTIMAL HEALTH: INTEGRATING EASTERN AND WESTEN PERSPECTIVES
影响因子：
--
作者：
Brown, Richard P.;Gerbarg, Patricia L.
通讯作者：
Gerbarg, Patricia L.