Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration.

Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration.
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DOI:
10.1038/ncomms4572
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发表时间:
2014-04-01
影响因子:
16.6
通讯作者:
Heck, D. H.
Heck, D. H.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Ito, J.;Roy, S.;Liu, Y.;Cao, Y.;Fletcher, M.;Lu, L.;Boughter, J. D.;Gruen, S.;Heck, D. H.

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目前的证据表明,大脑中的δ振荡(0.5 - 4hz)是由涉及皮质和丘脑回路的内在网络机制产生的。在这里,我们报道了清醒小鼠须桶皮层的峰峰和局部场电位(LFP)活动的δ带振荡与呼吸相锁定。此外,伽马频段(30-80 Hz)的LFP振荡与呼吸节律相振幅调制。嗅球的移除消除了呼吸锁定的delta振荡和delta-gamma相位振幅耦合。因此,我们的研究结果表明,呼吸锁定嗅球活动是清醒状态下须桶皮层δ振荡和伽马功率调制的主要驱动力。哺乳动物新皮层的振荡神经元活动与认知过程有关,但其产生机制尚不清楚。在这项研究中,作者表明,小鼠的δ波段振荡活动与呼吸活动相锁,这是由嗅球活动介导的。
Current evidence suggests that delta oscillations (0.5–4 Hz) in the brain are generated by intrinsic network mechanisms involving cortical and thalamic circuits. Here we report that delta band oscillation in spike and local field potential (LFP) activity in the whisker barrel cortex of awake mice is phase locked to respiration. Furthermore, LFP oscillations in the gamma frequency band (30–80 Hz) are amplitude modulated in phase with the respiratory rhythm. Removal of the olfactory bulb eliminates respiration-locked delta oscillations and delta-gamma phase-amplitude coupling. Our findings thus suggest respiration-locked olfactory bulb activity as a main driving force behind delta oscillations and gamma power modulation in the whisker barrel cortex in the awake state. Oscillatory neuronal activity in the mammalian neocortex is implicated in cognitive processes but its generation is poorly understood. In this study, the authors show that delta band oscillatory activity in mice phase-locks with respiratory activity and that this is mediated by activity in the olfactory bulb.
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