Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.
Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.
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DOI：
10.1371/journal.pone.0039541
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Health ABC and CARDIA Studies Groups
中科院分区：
文献类型：
--
作者：
Aldrich MC;Kumar R;Colangelo LA;Williams LK;Sen S;Kritchevsky SB;Meibohm B;Galanter J;Hu D;Gignoux CR;Liu Y;Harris TB;Ziv E;Zmuda J;Garcia M;Leak TS;Foreman MG;Smith LJ;Fornage M;Liu K;Burchard EG;Health ABC and CARDIA Studies Groups
吸烟会降低肺功能。与欧洲裔美国人相比，非洲裔美国人的肺功能较低，烟草烟雾的代谢也较低。非洲血统也与非洲裔美国人的肺功能较低有关。我们的目的是确定非洲血统是否改变了吸烟和肺功能之间的联系，以及非裔美国人的肺功能下降率。我们评估了一个前瞻性的正在进行的队列，1,281名非洲裔美国人参加了1997年开始的健康，衰老和身体成分（健康ABC）研究。我们还研究了一项正在进行的前瞻性队列研究，该研究始于1985年，共有1,223名非洲裔美国人参加了年轻人冠状动脉疾病（CARDIA）研究。肺功能和吸烟暴露在基线和重复随访期间进行了测量。个体遗传祖先的比例估计使用祖先信息标记选择区分欧洲和西非的祖先。与具有较低非洲血统的吸烟者（FEV 1/吸烟包-年为-4.6 ml）相比，具有高比例非洲血统的非裔美国人每吸烟包-年的基线一秒用力呼气量（FEV 1）较低（-5.7 ml FEV 1/吸烟包-年）（交互作用P值= 0.17）。 纵向分析揭示了吸烟和非洲血统之间的相互作用，健康ABC和CARDIA中独立复制的FEV 1下降率。具有高比例非洲血统的非裔美国人在吸烟时失去肺功能的风险更大。
Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans. We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV1) per pack-year of smoking (−5.7 ml FEV1/ smoking pack-year) compared with smokers with lower African ancestry (−4.6 ml in FEV1/ smoking pack-year) (interaction P value = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV1 decline in Health ABC and independently replicated in CARDIA. African American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking.
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影响因子：
3.9
作者：
Kosoy, Roman;Nassir, Rami;Tian, Chao;White, Phoebe A.;Butler, Lesley M.;Silva, Gabriel;Kittles, Rick;Alarcon-Riquelme, Marta E.;Gregersen, Peter K.;Belmont, John W.;De La Vega, Francisco M.;Seldin, Michael F.
通讯作者：
Seldin, Michael F.
DOI：
10.1164/rccm.200402-230oc
发表时间：
2005-01-15
影响因子：
24.7
作者：
James, AL;Palmer, LJ;Musk, AW
通讯作者：
Musk, AW
DOI：
10.1016/0197-2456(91)90002-4
发表时间：
1991-02-01
期刊：
Controlled clinical trials
影响因子：
--
作者：
Cutter, G R;Burke, G L;Manolio, T A
通讯作者：
Manolio, T A
影响因子：
5
作者：
Harik-Khan, RI;Muller, DC;Wise, RA
通讯作者：
Wise, RA
影响因子：
4.3
作者：
Dransfield, Mark T.;Davis, Jennifer J.;Bailey, William C.
通讯作者：
Bailey, William C.