Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter.
Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter.
复制标题
DOI：
10.1038/s42003-022-03587-3
复制
发表时间：
2022-06-29
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
迟缓爱德华氏菌（Edwardsiellatarda）是一种常见的细菌性病原体，其宿主范围广泛，包括鱼类、两栖动物和哺乳动物。E.迟发性是其较强的抵抗宿主血清补体杀伤的能力，但其机制尚不清楚。在本报告中，我们确定了E。tarda TraT作为补体抵抗和细胞侵袭的关键参与者。TraT是一种表面定位的蛋白质，可将补体因子H结合并募集到E. tarda，从而通过旁路途径抑制补体激活。TraT还以特异性补体控制蛋白结构域依赖的方式与宿主CD 46相互作用，从而促进E.迟到。因此，TraT作为一种抗补体因子和细胞感染促进因子，对E.迟到。这些结果为深入了解大肠杆菌侵染过程中病原-宿主相互作用机制提供了新的思路。迟发性感染迟缓爱德华氏菌TraT促进细胞感染，并作为一种抗补体因子，阐明了E. tarda对宿主杀戮的强烈逃避。
Edwardsiella tarda is a well-known bacterial pathogen with a broad range of host, including fish, amphibians, and mammals. One eminent virulence feature of E. tarda is its strong ability to resist the killing of host serum complement, but the involving mechanism is unclear. In this report, we identified E. tarda TraT as a key player in both complement resistance and cellular invasion. TraT, a surface-localized protein, bound and recruited complement factor H onto E. tarda, whereby inhibiting complement activation via the alternative pathway. TraT also interacted with host CD46 in a specific complement control protein domain-dependent manner, whereby facilitating the cellular infection and tissue dissemination of E. tarda. Thus, by acting as an anti-complement factor and a cellular infection promoter, TraT makes an important contribution to the complement evasion and systemic infection of E. tarda. These results add insights into the pathogen-host interaction mechanism during E. tarda infection. Edwardsiella tarda TraT promotes cellular infection and serves as an anti-complement factor, shedding light on the mechanisms of E. tarda’s strong evasion of killing by the host.
登录
查看更多内容
影响因子：
7.3
作者：
Józsi M
通讯作者：
Józsi M
DOI：
10.1073/pnas.74.11.5104
发表时间：
1977-01-01
影响因子：
11.1
作者：
ACHTMAN, M;KENNEDY, N;SKURRAY, R
通讯作者：
SKURRAY, R
影响因子：
4.6
作者：
Beeg, Marten;Nobili, Alessandro;Gobbi, Marco
通讯作者：
Gobbi, Marco
影响因子：
5.4
作者：
Brangulis, Kalvis;Petrovskis, Ivars;Tars, Kaspars
通讯作者：
Tars, Kaspars
影响因子：
4.4
作者：
Barilla-LaBarca, ML;Liszewski, MK;Atkinson, JP
通讯作者：
Atkinson, JP