Overexpression of CDK2 is a prognostic indicator of oral cancer progression.
Overexpression of CDK2 is a prognostic indicator of oral cancer progression.
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DOI：
10.1111/j.1349-7006.2001.tb01102.x
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发表时间：
2001-03
期刊：
影响因子：
--
通讯作者：
Wong DT
中科院分区：
文献类型：
--
作者：
Mihara M;Shintani S;Nakahara Y;Kiyota A;Ueyama Y;Matsumura T;Wong DT
细胞周期蛋白和细胞周期蛋白依赖性激酶（CDK）在细胞周期调控中起关键作用，这一过程的失调可导致细胞生长失控，从而导致癌症。我们已经报道了口腔癌中CDK4和cyclin D1表达的改变。在这项研究中，我们检测了20例正常口腔粘膜，42例不典型增生上皮和103例口腔鳞状细胞癌（SCC）中CDK 2和细胞周期蛋白A和E的表达。CDK2、cyclins A和E在正常上皮中均未检测到表达，而在上皮不典型增生至SCC中表达有明显变化。cyclins A、E的表达与患者的生存期无明显相关性，而CDK2的表达与淋巴结转移（P=0.025）、肿瘤分化程度（P=0.032）、肿瘤浸润方式（P=0.017）和较短的生存期（P=0.0173）显著相关。这些结果表明，CDK2的高表达是口腔癌进展的关键因素，并可用作患者预后的阴性预测标志物。
Cyclins and cyclin‐dependent kinases (CDKs) play key roles in cell cycle regulation, a process of which dysregulation can lead to uncontrolled cell growth and hence to cancer. We have already reported the alteration of CDK4 and cyclin Dl expression in oral cancer. In this study, we examined by immunohistochemistry the expression of CDK2, and cyclins A and E in 20 normal oral mucosa, 42 dysplastic epithelia, and 103 oral squamous cell carcinomas (SCCs). The expressions of CDK2, and cyclins A and E were not detected in the normal epithelium and significantly altered from epithelial dysplasia to SCC. While there were no significant correlations between the expression of cyclins A, E and the patients' survival, CDK2 expression was significantly correlated with lymph node involvement (P=0.025), tumor differentiation (P=0.032), mode of tumor invasion (P=0.017), and shorter survival period (P=0.0173). These results suggest that the elevated expression of CDK2 is a critical factor in oral cancer progression and can be used as a negative predictive marker of the patients' prognosis.
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