Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer.
Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer.
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DOI：
10.1111/jcmm.13696
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发表时间：
2018-10
影响因子：
5.3
通讯作者：
Tanaka Y
中科院分区：
文献类型：
--
作者：
Kato T;Hashimoto Y;Wong RK;Mitsui Y;Maekawa S;Chang I;Shahryari V;Yamamura S;Majid S;Saini S;Tabatabai ZL;Dahiya R;Deguchi T;Tanaka Y
细胞色素P450 1B 1（CYP 1B 1）将外源性物质转化为致癌物质，并评估了生活方式选择如何与CYP 1B 1多态性相互作用并影响前列腺癌风险。采用TaqMan基因分型法分析了高加索人群血液基因组DNA中CYP 1B 1 5′非翻译区的多态性位点。总的来说，饮酒状态和rs 2551188、rs 2567206和rs 10175368的次要等位基因与前列腺癌相关。在rs 2551188、rs 2567206、rs 2567207和rs 10175368之间观察到连锁，并且在癌症中G-C-T-G单倍型（相应位点的主要等位基因）减少。有趣的是，当按生活方式因素分类时，未发现非吸烟者和非饮酒者的基因型相关性，相反，在吸烟者和饮酒者中，rs 2567206和rs 10175368的次要类型增加，而主要G-C-T-G降低癌症风险。有趣的是，rs 2551188、rs 2567206和rs 10175368次要基因型与组织CYP 1B 1增加相关，如通过免疫组织化学测定的。此外，rs 10175368增强的荧光素酶活性和迁移率变化显示核因子对次要等位基因的更强结合。这些结果表明，吸烟和饮酒可以改变前列腺癌的CYP 1B 1多态性的风险，这可能是通过rs 10175368，这是重要的，在了解其在发病机制中的作用，并作为这种疾病的生物标志物。
Cytochrome P450 1B1 (CYP1B1) converts xenobiotics to carcinogens and how lifestyle choices may interact with CYP1B1 polymorphisms and affect prostate cancer risk was assessed. Blood genomic DNA from a Caucasian population was analysed at polymorphic sites of the 5′ untranslated region of CYP1B1 using TaqMan genotyping assays. Overall, drinker status and minor alleles at rs2551188, rs2567206 and rs10175368 were associated with prostate cancer. Linkage was observed between rs2551188, rs2567206, rs2567207 and rs10175368, and the G‐C‐T‐G haplotype (major allele at respective sites) was decreased in cancer. Interestingly when classified by lifestyle factors, no associations of genotypes were found for non‐smokers and non‐drinkers, whereas on the contrary, minor type at rs2567206 and rs10175368 increased and major G‐C‐T‐G decreased risk for cancer among smokers and drinkers. Interestingly, rs2551188, rs2567206 and rs10175368 minor genotypes correlated with increased tissue CYP1B1 as determined by immunohistochemistry. Further, rs10175368 enhanced luciferase activity and mobility shift show stronger binding of nuclear factor for the minor allele. These results demonstrate smoking and alcohol consumption to modify the risks of CYP1B1 polymorphisms for prostate cancer which may be through rs10175368, and this is of importance in understanding their role in the pathogenesis and as a biomarker for this disease.
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在不存在或存在叶绿素的情况下，在正常的人类乳腺上皮细胞中，正常的人类乳腺上皮细胞中的CYP1A1和CYP1B1基因表达和DNA加合物形成。
影响因子：
9.7
作者：
John, Kaarthik;Divi, Rao L.;Keshava, Channa;Orozco, Christine C.;Schockley, Marie E.;Richardson, Diana L.;Poirier, Miriam C.;Nath, Joginder;Weston, Ainsley
通讯作者：
Weston, Ainsley
影响因子：
23.4
作者：
Islami F;Moreira DM;Boffetta P;Freedland SJ
通讯作者：
Freedland SJ
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
4.7
作者：
Beuten J;Gelfond JA;Byrne JJ;Balic I;Crandall AC;Johnson-Pais TL;Thompson IM;Price DK;Leach RJ
通讯作者：
Leach RJ
影响因子：
3.5
作者：
Hamitouche, S.;Poupon, J.;Lucas, D.
通讯作者：
Lucas, D.