The role of astrocytes in place cell formation: A computational modeling study.
The role of astrocytes in place cell formation: A computational modeling study.
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DOI：
10.1007/s10827-022-00828-6
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发表时间：
2022-11
影响因子：
1.2
通讯作者：
Michmizos, Konstantinos P.
中科院分区：
文献类型：
--
作者：
Polykretis, Ioannis;Michmizos, Konstantinos P.
在探索新环境的早期阶段，位置细胞会产生空间调谐的感受野。这些空间选择性反应的生成机制在很大程度上仍然难以捉摸，但已与θ节律。一个重要的因素牵连沉默细胞的位置细胞的转化是一个空间上一致的去极化，介导的持续钠电流。这种神经元电流受细胞外钙浓度的调节，而细胞外钙浓度又受星形胶质细胞的主动控制。然而，神经元去极化和星形胶质细胞活性之间没有确定的关系。考虑到这种联系，我们设计了一个生物合理的计算模型的神经元-星形胶质细胞网络，星形胶质细胞诱导沉默细胞的位置字段的短暂出现，并加速了可塑性诱导的巩固的位置细胞。有趣的是，θ振荡自然出现在网络水平，从星形胶质细胞的亚细胞神经元特性的调制。我们的研究结果表明，星形胶质细胞参与空间映射和探索，并进一步突出了这些细胞在大脑中的计算作用。
Place cells develop spatially-tuned receptive fields during the early stages of novel environment exploration. The generative mechanism underlying these spatially-selective responses remains largely elusive, but has been associated with theta rhythmicity. An important factor implicating the transformation of silent cells to place cells is a spatially-uniform depolarization that is mediated by a persistent sodium current. This neuronal current is modulated by extracellular calcium concentration, which, in turn, is actively controlled by astrocytes. However, there is no established relationship between the neuronal depolarization and astrocytic activity. To consider this link, we designed a bioplausible computational model of a neuronal-astrocytic network, where astrocytes induced the transient emergence of place fields in silent cells, and accelerated the plasticity-induced consolidation of place cells. Interestingly, theta oscillations emerged naturally at the network level, resulting from the astrocytic modulation of subcellular neuronal properties. Our results suggest that astrocytes participate in spatial mapping and exploration, and further highlight the computational roles of these cells in the brain.
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