Vaccine-induced time- and age-dependent mucosal immunity to gastrointestinal parasite infection.
Vaccine-induced time- and age-dependent mucosal immunity to gastrointestinal parasite infection.
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DOI：
10.1038/s41541-022-00501-0
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发表时间：
2022-07-07
期刊：
影响因子：
9.2
通讯作者：
中科院分区：
文献类型：
--
作者：
个体对疫苗接种和随后的攻毒感染的反应差异很大，疫苗应答不良导致感染和传播在人群中持续存在。然而，尽管具有重大的经济和社会影响，但这种变异性的免疫机制，特别是在感染组织中，仍然知之甚少。在这里，如何抗蠕虫免疫接种疫苗的羔羊感染的粘膜部位，我们插入胃插管到皱胃的3个月和6个月大的羔羊和纵向分析其局部免疫反应在随后的挑战感染。该疫苗诱导了攻毒前真胃免疫谱的广泛变化，并降低了攻毒后的寄生虫负荷和卵产量，与年龄无关。然而，年龄影响了接种疫苗的羔羊对多种免疫途径感染的反应：适应性免疫途径通常依赖于年龄。识别年龄依赖性和年龄非依赖性保护性免疫途径可能有助于改进疫苗的配方，并更普遍地指示病原体特异性免疫的特异性。
Individuals vary broadly in their response to vaccination and subsequent challenge infection, with poor vaccine responders causing persistence of both infection and transmission in populations. Yet despite having substantial economic and societal impact, the immune mechanisms that underlie such variability, especially in infected tissues, remain poorly understood. Here, to characterise how antihelminthic immunity at the mucosal site of infection developed in vaccinated lambs, we inserted gastric cannulae into the abomasa of three-month- and six-month-old lambs and longitudinally analysed their local immune response during subsequent challenge infection. The vaccine induced broad changes in pre-challenge abomasal immune profiles and reduced parasite burden and egg output post-challenge, regardless of age. However, age affected how vaccinated lambs responded to infection across multiple immune pathways: adaptive immune pathways were typically age-dependent. Identification of age-dependent and age-independent protective immune pathways may help refine the formulation of vaccines, and indicate specificities of pathogen-specific immunity more generally.
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影响因子：
5.4
作者：
Faulkner, H;Humphreys, N;Grencis, R
通讯作者：
Grencis, R
影响因子：
--
作者：
Clements, John D.;Freytag, Lucy C.
通讯作者：
Freytag, Lucy C.
影响因子：
46.9
作者：
Bray, Nicolas L.;Pimentel, Harold;Pachter, Lior
通讯作者：
Pachter, Lior
影响因子：
3.3
作者：
Corpa, JM;Pérez, V;Marín, JFG
通讯作者：
Marín, JFG
影响因子：
9.2
作者：
Braun RO;Brunner L;Wyler K;Auray G;García-Nicolás O;Python S;Zumkehr B;Gaschen V;Stoffel MH;Collin N;Barnier-Quer C;Bruggmann R;Summerfield A
通讯作者：
Summerfield A